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The Functions of Klarsicht and Nuclear Lamin in Developmentally Regulated Nuclear Migrations of Photoreceptor Cells in the Drosophila Eye
Open accessAbstract
Photoreceptor nuclei in the Drosophila eye undergo developmentally regulated migrations. Nuclear migration is known to require the perinuclear protein Klarsicht, but the function of Klarsicht has been obscure. Here, we show that Klarsicht is required for connecting the microtubule organizing center (MTOC) to the nucleus. In addition, in a genetic screen for klarsicht-interacting genes, we identified Lam Dm 0, which encodes nuclear lamin. We find that, like Klarsicht, lamin is required for photoreceptor nuclear migration and for nuclear attachment to the MTOC. Moreover, perinuclear localization of Klarsicht requires lamin. We propose that nuclear migration requires linkage of the MTOC to the nucleus through an interaction between microtubules, Klarsicht, and lamin. The Klarsicht/lamin interaction provides a framework for understanding the mechanistic basis of human laminopathies.
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Cited by
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Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 834
Bidirectional transport along microtubules
Welte, M. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.045 · Cited by 577
Broers, J. L. V., Peeters, E. A. G., Kuijpers, H. J. H., Endert, J., Bouten, C. V. C., Oomens, C. W. J., Baaijens, F. P. T., & Ramaekers, F. C. S. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh295 · Cited by 359
Zhang, Q., Ragnauth, C. D., Skepper, J. N., Worth, N. F., Warren, D. T., Roberts, R. G., Weissberg, P. L., Ellis, J. A., & Shanahan, C. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.01642 · Cited by 277
Local translation of extranuclear lamin B promotes axon maintenance
Yoon, B. C., Jung, H., Dwivedy, A., O'Hare, C. M., Zivraj, K. H., & Holt, C. E. (2012) · Cell · doi:10.1016/j.cell.2011.11.064 · Cited by 263
Metadata
- Authors
- Patterson, K., Molofsky, A. B., Robinson, C., Acosta, S., Cater, C., & Fischer, J. A.
- Venue
- Molecular Biology of the Cell
- Published
- 2004-02
- Volume
- 15
- Issue
- 2
- Pages
- 600-610
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2118261741
- Cited by
- 163
- References
- 0
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Patterson, K., Molofsky, A. B., Robinson, C., Acosta, S., Cater, C., & Fischer, J. A. (2004). The Functions of Klarsicht and Nuclear Lamin in Developmentally Regulated Nuclear Migrations of Photoreceptor Cells in the Drosophila Eye. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e03-06-0374
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