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Two Human Orthologues of Eco1/Ctf7 Acetyltransferases Are Both Required for Proper Sister-Chromatid Cohesion
Open accessAbstract
Genetic studies in yeast and Drosophila have uncovered a conserved acetyltransferase involved in sister-chromatid cohesion. Here, we described the two human orthologues, previously named EFO1/ESCO1 and EFO2/ESCO2. Similar to their yeast (Eco1/Ctf7 and Eso1) and fly (deco) counterparts, both proteins feature a conserved C-terminal domain consisting of a H2C2 zinc finger motif and an acetyltransferase domain that is able to catalyze autoacetylation reaction in vitro. However, no similarity can be detected outside of the conserved domain. RNA interference depletion experiment revealed that EFO1/ESCO1 and EFO2/ESCO2 were not redundant and that both were required for proper sister-chromatid cohesion. The difference between EFO1 and EFO2 also is reflected in their cell cycle regulation. In mitosis, EFO1 is phosphorylated, whereas EFO2 is degraded. Furthermore, both proteins associate with chromosomes, and the chromosome binding depends on the diverse N-terminal domains. We propose that EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion.
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Citations
Cited by
The cohesin complex and its roles in chromosome biology
Peters, J.-M., Tedeschi, A., & Schmitz, J. (2008) · Genes & Development · doi:10.1101/gad.1724308 · Cited by 532
Gandhi, R., Gillespie, P. J., & Hirano, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.061 · Cited by 441
Zhang, J., Shi, X., Li, Y., Kim, B.-J., Jia, J., Huang, Z., Yang, T., Fu, X., Jung, S. Y., Wang, Y., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.006 · Cited by 421
Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl
Nishiyama, T., Ladurner, R., Schmitz, J., Kreidl, E., Schleiffer, A., Bhaskara, V., Bando, M., Shirahige, K., Hyman, A. A., Mechtler, K., et al. (2010) · Cell · doi:10.1016/j.cell.2010.10.031 · Cited by 391
PCNA Controls Establishment of Sister Chromatid Cohesion during S Phase
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.007 · Cited by 282
Metadata
- Authors
- Hou, F., & Zou, H.
- Venue
- Molecular Biology of the Cell
- Published
- 2005-08
- Volume
- 16
- Issue
- 8
- Pages
- 3908-3918
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2132200096
- Cited by
- 207
- References
- 0
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Two Human Orthologues of Eco1/Ctf7 Acetyltransferases Are Both Required for Proper Sister-Chromatid Cohesion. https://app.cochat.ai/papers/10.1091/mbc.e04-12-1063
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- Hou, F., & Zou, H. (2005). Two Human Orthologues of Eco1/Ctf7 Acetyltransferases Are Both Required for Proper Sister-Chromatid Cohesion. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e04-12-1063
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