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Cited by 26Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamicsCellular transport and secretion

Tau differentially regulates the transport of early endosomes and lysosomes

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Balabanian, Linda, Lessard, Dominique V., Swaminathan, Karthikeyan, Yaninska, Pamela, Sébastien, Muriel, Wang, Samuel, Stevens, Piper W., Wiseman, Paul W. +2 more·2022·Molecular Biology of the Cell
DOI 10.1091/mbc.e22-01-0018PMC PMC9634973

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Abstract

Different vesicular cargoes have distinct responses to tau phosphorylation. Phosphomimetic (Y18E) tau has a weakened effect on lysosome motility compared with unphosphorylated tau and preferentially inhibits peripheral lysosomes. In contrast, early endosomes are strongly inhibited by both unphosphorylated and phosphomimetic tau.

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  • Mutations at Y18 increase tau dynamics on microtubules, reduce tau accumulation, and impair tau-mediated regulation of intracellular transport.

    “mutations at Y18, the terminal residue of PAD, increase tau dynamics on microtubules, reduce tau accumulation, and impair tau-mediated regulation of intracellular transport”

    From Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons (2026) · cites this paper as Balabanian et al., 2022

    The Introduction (page unavailable) reports that phosphomimetic Y18E tau has reduced microtubule affinity and increased diffusivity, while the Discussion proposes that a negative charge at Y18 may favor dynamic microtubule binding. The Results (page unavailable) show reduced tau-mediated inhibition of lysosome transport at low Y18E expression, but stronger inhibition of early-endosome motility; the effect on transport is therefore cargo-dependent. Our copy does not establish reduced tau accumulation, and it presents the proposed change in binding dynamics more cautiously than the claim. (LLM, conf=0.86)

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Authors
Balabanian, L., Lessard, D. V., Swaminathan, K., Yaninska, P., Sébastien, M., Wang, S., Stevens, P. W., Wiseman, P. W., Berger, C. L., & Hendricks, A. G.
Affiliations
  • McGill University (CA)
  • University of Vermont (US)
Corresponding author
Hendricks, Adam G.
ORCID
Venue
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Published
2022-11-01
Volume
33
Issue
13
Pages
ar128-ar128
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
DOI
10.1091/mbc.e22-01-0018
PMC
PMC9634973
OpenAlex
W4296703669
Cited by
26
References
3
Citations by year
2026: 6 · 2025: 8 · 2024: 5 · 2023: 4 · 2022: 3
FWCI
3.02
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Molecular Biology of the Cell (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Funders
  • McGill University
  • National Institutes of Health
  • Canadian Institutes of Health Research (159490_1)
  • Natural Sciences and Engineering Research Council of Canada (RGPIN 2017 ?, rgpin-2017-05005)
  • National Institute of General Medical Sciences (R01GM132646)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
tau protein, early endosomes, lysosomes, organelle transport, kinesin-1, kinesin-3, kinesin-2, dynein, Fyn, microtubule-associated proteins, vesicle motility, cargo specificity
MeSH terms
Biological Transport, Dyneins, Lysosomes, Microtubule-Associated Proteins, Microtubules, Endosomes, Kinesins, tau Proteins

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