Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins
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Abstract
Ank1 binds the myosin-1 (Myo1) and prevents its membrane and endocytic patch localization. Structural predications suggest that the (Ank1) ankyrin repeats bind the Myo1 motor while the Ank1 acidic C-terminus masks positive charges necessary for Myo1 membrane association. This regulatory mechanism appears to be evolutionarily conserved.
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Highly accurate protein structure prediction with AlphaFold
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- Authors
- Willet, A. H., Chen, J.-S., Ren, L., & Gould, K. L.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Gould, Kathleen L.
- Venue
- Molecular Biology of the Cell
- Published
- 2023-10-01
- Volume
- 34
- Issue
- 11
- Pages
- br17-br17
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC10559312
- OpenAlex
- W4385497939
- Cited by
- 2
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nd
- Locations
- Molecular Biology of the Cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nd)
- Funders
- National Institute of General Medical Sciences (R35GM131799)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- ankyrin repeat proteins, endocytosis, membrane binding, ANK1, lever arm, cytoplasmic sequestration, plasma membrane localization, Saccharomyces cerevisiae, liposome binding
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