The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion
Abstract
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is suggested to be a long (~7 kb) non-coding RNA. MALAT1 is overexpressed in many human carcinomas, but its function remains unknown. To investigate the role of MALAT1 in human cervical cancer progression, we designed and used short hairpin RNA to inhibit MALAT1 expression in CaSki cells and validated its effect on cell proliferation and invasion. Changes in gene expression were analyzed by reverse transcriptase- polymerase chain reaction. Our data demonstrated that MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL, suggesting that MALAT1 could have important implications in cervical cancer biology. Our findings illustrate the biological significance of MALAT1 in cervical cancer progression and provide novel evidence that MALAT1 may serve as a therapeutic target in the prevention of human cervical cancer.
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Cites
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Cited by
The functional role of long non-coding RNA in human carcinomas
Gibb, E. A., Brown, C. J., & Lam, W. L. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-38 · Cited by 1,619
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Gutschner, T., Hämmerle, M., Eißmann, M., Hsu, J., Kim, Y., Hung, G., Revenko, A., Arun, G., Stentrup, M., Groß, M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2850 · Cited by 1,415
Long non-coding RNAs: A new frontier in the study of human diseases
Shi, X., Sun, M., Liu, H., Yao, Y., & Song, Y. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.06.013 · Cited by 1,150
MALAT1 — a paradigm for long noncoding RNA function in cancer
Gutschner, T., Hämmerle, M., & Diederichs, S. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1028-y · Cited by 719
lncRNAs and microRNAs with a role in cancer development
Liz, J., & Esteller, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.06.015 · Cited by 512
Metadata
- Authors
- Guo, F., Li, Y., Liu, Y., Wang, J., Li, Y., & Li, G.
- Venue
- Acta Biochimica et Biophysica Sinica
- Published
- 2010-03-01
- Volume
- 42
- Issue
- 3
- Pages
- 224-229
- ISSN
- 1672-9145 (ISSN-L)
- OpenAlex
- W2107685513
- Cited by
- 237
- References
- 1
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. https://app.cochat.ai/papers/10.1093/abbs/gmq008
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- Guo, F., Li, Y., Liu, Y., Wang, J., Li, Y., & Li, G. (2010). Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochimica et Biophysica Sinica. https://doi.org/10.1093/abbs/gmq008
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