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Endocrine Disruptors, Brain, and Behavior
Abstract
Hormones play a foundational role in the sex-specific organization of the brain and, consequently, the complex behaviors they coordinate. Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with hormone action and thus, possibly, our neural and mental health. If and how these endocrine-disrupting compounds (EDCs) affect the development and function of the brain, and may be contributing to neural disorders that are rapidly rising in prevalence, are the central concerns of this book. This work also examines why even the concept of endocrine disruption is controversial in some circles; how differing definitions of endocrine disruption and “adverse” outcomes shape public policy; and where the current capacity to evaluate chemicals for safety in a regulatory context begins and ends. Fundamental concepts of the EDC hypothesis, including critical windows of exposure and sexually dimorphic effects, are explained. A historical perspective on how the endocrine disruption hypothesis emerged and a summary of how and to what degree prototypical EDCs affect human brain health are provided as a prelude to a critical evaluation of the evidence linking EDC exposures to human neurobehavioral disorders. The book concludes with suggestions for future research needs and a summary of emerging technology that might prove more capable of effectively evaluating existing and new chemicals for endocrine-disrupting properties. The impossibility of disentangling the “science” of EDC action on the brain and behavior from its public health policy implications and economic influence is comprehensively addressed throughout.
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“Consequently, daily exposure is virtually silent and unceasingly increasing (12).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [12]
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Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166
Self-citationEnvironmental Mechanisms of Neurodevelopmental Toxicity
Rock, K. D., & Patisaul, H. B. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0185-0 · Cited by 136
Self-citationEndocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54
Self-citationGillera, S. E. A., Marinello, W. P., Horman, B. M., Phillips, A. L., Ruis, M. T., Stapleton, H. M., Reif, D. M., & Patisaul, H. B. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2019.106840 · Cited by 48
Self-citationThresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective
DEMENEIX, B. A., Vandenberg, L. N., Ivell, R., & Zoeller, R. T. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa085 · Cited by 47
Patisaul, H. B. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.03.007 · Cited by 44
Self-citationComposition and endocrine effects of water collected in the Kibale national park in Uganda
Špirhanzlová, P., Fini, J., DEMENEIX, B. A., Lardy‐Fontan, S., Vaslin-Reimann, S., Lalère, B., Guma, N., Tindall, A. J., & Krief, S. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.05.006 · Cited by 39
Neurotoxicants, the Developing Brain, and Mental Health
Cardenas‐Iniguez, C., Burnor, E., & Herting, M. M. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.05.002 · Cited by 45
Maradonna, F., Vandenberg, L. N., & Meccariello, R. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.886628 · Cited by 20
Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development
Marinello, W. P., & Patisaul, H. B. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.04.003 · Cited by 17
Self-citationGillera, S. E. A., Marinello, W. P., Nelson, M. A., Horman, B. M., & Patisaul, H. B. (2022) · Toxics · doi:10.3390/toxics10050268 · Cited by 11
Self-citationBerntsson, S. G., Reis, J. J., Tülek, Z., Spencer, P. S., Imhoff, M., Joao, M., Lafta, M. S., Najar, Y., Tolf, A., Selander, V., et al. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.123117 · Cited by 8
Vandenberg, L. N., & Pelch, K. E. (2021) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530321666211005163614 · Cited by 10
Alymbaeva, D., Szabó, C., Jócsák, G., Bartha, T., Zsarnovszky, A., Kővágó, C., Ondrašovičová, S., & Kiss, D. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303528 · Cited by 5
Kourkopoulos, A., Sijm, D. T. H. M., Mircheva, A., Bastos, V. C., & Vrolijk, M. F. (2025) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2025.105816 · Cited by 5
Rock, K. D., Starnes, H. M., & Belcher, S. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00420-6 · Cited by 7
Self-citationMarinello, W. P., Gillera, S. E. A., Huang, L., Rollman, J., Reif, D. M., & Patisaul, H. B. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.10.012 · Cited by 2
Self-citationMental Health Disorders Following Exposure to Endocrine Disruptor Chemicals
Ehsanifar, M., Gholami, A., & Esmaeili, A. (2025) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2502285 · Cited by 2
Vandenberg, L. N., & Kolla, S. (2018) · doi:10.1093/obo/9780199363445-0104 · Cited by 2
Corporate Social Responsibility and Accounting for Externalities
de Lautour, V. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-20157-9_3
Metadata
- Authors
- Patisaul, H. B., & Belcher, S. M.
- Venue
- Oxford Scholarship Online
- Publisher
- Oxford University Press
- Published
- 2017-05-18
- OpenAlex
- W4251073647
- Cited by
- 20
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 2.60
- Type
- book
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- endocrine disruptors, brain development, neurobehavioral disorders, hormone action, critical windows of exposure, chemical safety regulation, public health policy, chemical exposure
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