The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Perspective: Physiologic Importance of Short-Chain Fatty Acids from Nondigestible Carbohydrate Fermentation
Open accessAbstract
In recent years, it has become increasingly obvious that dietary fiber or nondigestible carbohydrate (NDC) consumption is critical for maintaining optimal health and managing symptoms of metabolic disease. In accordance with this, the US FDA released its first official definition of dietary fiber in 2016 for regulation of Nutrition and Supplement Facts labels. Included in this definition is the requirement of an isolated or synthetic NDC to produce an accepted physiologic health benefit, such as improved laxation or reduced fasting cholesterol concentrations, upon consumption. Even though NDC fermentation and production of short-chain fatty acids elicit many physiologic effects, including serving as a source of energy for colonocytes, curbing glycemic response and satiety, promoting weight loss, enhancing mineral absorption, reducing systemic inflammation, and improving intestinal health, the process of fermentation is not considered a physiologic endpoint. Instead, expensive and laborious clinical trials must be conducted and an accepted physiologic benefit observed. In this review, we discuss the physiologic importance of NDC fermentation through extensive examination of clinical evidence and propose that the degree of fermentability of an NDC, rather than the endpoints of a clinical trial, may be appropriate for classifying it as a dietary fiber.
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Cites
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., et al. (2018) · Science · doi:10.1126/science.aao5774 · Cited by 2,304
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093
Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970
Scholz-Ahrens, K. E., Ade, P., Marten, B., Weber, P., Timm, W., Asil, Y., Glüer, C.-C., & Schrezenmeir, J. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.838s · Cited by 591
Benjamin, J. L., Hedin, C. R. H., Koutsoumpas, A., Ng, S. C., McCarthy, N. E., Hart, A. L., Kamm, M. A., Sanderson, J. D., Knight, S. C., Forbes, A., et al. (2011) · Gut · doi:10.1136/gut.2010.232025 · Cited by 361
Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.166132 · Cited by 349
Towards microbial fermentation metabolites as markers for health benefits of prebiotics
Verbeke, K. A., Boobis, A. R., Chiodini, A., Edwards, C. A., Franck, A., Kleerebezem, M., Nauta, A., Raes, J., van Tol, E. A. F., & Tuohy, K. M. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000037 · Cited by 343
Müller, M., Canfora, E., & Blaak, E. (2018) · Nutrients · doi:10.3390/nu10030275 · Cited by 329
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Ma, J., Piao, X., Mahfuz, S., Long, S., & Wang, J. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2021.09.012 · Cited by 398
The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review
Hughes, R. L., Alvarado, D. A., Swanson, K. S., & Holscher, H. D. (2022) · Advances in Nutrition · doi:10.1093/advances/nmab119 · Cited by 293
Self-citationThe Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives
Giuntini, E. B., Sardá, F. A. H., & de Menezes, E. W. (2022) · Foods · doi:10.3390/foods11233934 · Cited by 256
Alvandi, E., Wong, W. K. M., Joglekar, M. V., Spring, K. J., & Hardikar, A. A. (2022) · BMC Medicine · doi:10.1186/s12916-022-02529-4 · Cited by 101
Early changes of fecal short‐chain fatty acid levels in patients with mild cognitive impairments
Gao, C., Li, B., He, Y., Huang, P., Du, J., He, G., Zhang, P., Tang, H., & Chen, S. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14252 · Cited by 50
Metadata
- Authors
- Alexander, C., Swanson, K. S., Fahey, G. C., & Garleb, K. A.
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 10
- Issue
- 4
- Pages
- 576-589
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- OpenAlex
- W2941981307
- Cited by
- 212
- References
- 16
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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