Cytomegalovirus infection and Alzheimer’s disease
Abstract
Serum antibody titres to cytomegalovirus (CMV) were measured in 113 patients with Alzheimer's disease (AD), and 39 non-demented controls suffering from chronic functional psychoses. AD patients and controls had similar CMV antibody titres, and conventional CMV activity was not detected in post-mortem samples from eight AD patients. It is therefore unlikely that the CMV play any causal role in most cases of AD. The possession of the histocompatibility antigen HLA-B15 was significantly correlated with raised levels of CMV antibody in the AD patients, which suggests that HLA-B15 may be associated with an enhanced immune response to CMV.
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Earlier studies found substantial differences in IgG titers in AD patients compared to controls, but subsequent studies found no association in ante-mortem or post-mortem AD versus controls for CMV.
“Although earlier studies found substantial differences in IgG titers in AD patients compared to controls [51], subsequent studies found no association in ante-mortem [52] or post-mortem [53] AD versus controls for CMV.”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [53]
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What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease?
Brutkiewicz, R. R., Cao, W., Morgan, D., Reis, R. S. D., Suryadevara, V., Willette, A. A., Willette, S. A., Wyatt-Johnson, S. K., & Duggan, M. R. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.05.009 · Cited by 3 · see citing works
- Authors
- RENVOIZE, E. B., & HAMBLING, M. H.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 1984
- Volume
- 13
- Issue
- 4
- Pages
- 205-209
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2048117480
- Cited by
- 27
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Age and Ageing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cytomegalovirus infection, Alzheimer's disease, HLA-B15, histocompatibility antigens
- MeSH terms
- Aged, Alzheimer Disease, Antibodies, Viral, Cytomegalovirus Infections, Cytomegalovirus, Female, HLA Antigens, Humans, Male, Middle Aged, HLA-B Antigens, HLA-B15 Antigen
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