A sero-epidemiological study of conventional infectious agents in Alzheimer’s disease
Abstract
Serum antibody titres to Adenovirus, Chlamydia Group B, Coxiella burnettii, Cytomegalovirus, Herpes simplex virus, Influenza A, Influenza B, Measles and Mycoplasma pneumoniae were measured in 33 patients with a clinical diagnosis of Alzheimer's disease, and in 28 non-demented controls suffering from functional psychiatric disorders. No statistically significant differences were found between the patients and controls, and it is concluded that these agents play no role in the aetiology of Alzheimer's disease.
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Earlier studies found substantial differences in IgG titers in AD patients compared to controls, but subsequent studies found no association in ante-mortem or post-mortem AD versus controls for CMV.
“Although earlier studies found substantial differences in IgG titers in AD patients compared to controls [51], subsequent studies found no association in ante-mortem [52] or post-mortem [53] AD versus controls for CMV.”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [52]
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Cited by 59
- Authors
- RENVOIZE, E. B., AWAD, L. O., & HAMBLING, M. H.
- Affiliations
- St James's University Hospital (GB)
- Corresponding author
- RENVOIZE, E. B.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 16
- Issue
- 5
- Pages
- 311-314
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2060441194
- Cited by
- 59
- References
- 0
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Age and Ageing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, infectious agents, etiology, serum antibody titres, adenovirus, chlamydia, Coxiella burnetii, cytomegalovirus, herpes simplex virus, influenza, measles, Mycoplasma pneumoniae, seroepidemiology, functional psychiatric disorders
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Antibodies, Bacterial, Antibodies, Viral, Bacterial Infections, Female, Humans, Male, Middle Aged, Virus Diseases
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