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Cited by 181Hormonal and reproductive studiesDiet, Metabolism, and DiseaseNutritional Studies and Diet

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feeding study

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Dorgan, JF, Judd, JT, Longcope, C, Brown, C, Schatzkin, A, Clevidence, BA, Campbell, WS, Nair, PP, Franz, C, Kahle, L, Taylor, PR·1996·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/64.6.850
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Abstract

We conducted a controlled feeding study to evaluate the effects of fat and fiber consumption on plasma and urine sex hormones in men. The study had a crossover design and included 43 healthy men aged 19-56 y. Men were initially randomly assigned to either a low-fat, high-fiber or high-fat, low-fiber diet for 10 wk and after a 2-wk washout period crossed over to the other diet. The energy content of diets was varied to maintain constant body weight but averaged approximately 13.3 MJ (3170 kcal)/d on both diets. The low-fat diet provided 18.8% of energy from fat with a ratio of polyunsaturated to saturated fat (P:S) of 1.3, whereas the high-fat diet provided 41.0% of energy from fat with a P:S of 0.6. Total dietary fiber consumption from the low- and high-fat diets averaged 4.6 and 2.0 g.MJ-1.d-1, respectively. Mean plasma concentrations of total and sex-hormone-binding-globulin (SHBG)-bound testosterone were 13% and 15% higher, respectively, on the high-fat, low-fiber diet and the difference from the low-fat, high-fiber diet was significant for the SHBG-bound fraction (P = 0.04). Men's daily urinary excretion of testosterone also was 13% higher with the high-fat, low-fiber diet than with the low-fat, high-fiber diet (P = 0.01). Conversely, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were 12-28% lower with the high-fat, low-fiber diet (P < or = 0.01). Results of this study suggest that diet may alter endogenous sex hormone metabolism in men.

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  1. Graham, 1983, Diet in the epidemiology of carcinoma of the prostate gland., J Natl Cancer Inst, 70, 687
  2. 1983, 1983 Height and weight tables, Stat Bull Metropol Insur Co, 64, 2
  3. Horton, 1986, Ideal conditions for hydrolysis of androstane-3cr,17/3-diol glucuronide in plasma., J Clin Endocrinol Metab, 62, 22

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Metadata

Authors
Dorgan, J., Judd, J., Longcope, C., Brown, C., Schatzkin, A., Clevidence, B., Campbell, W., Nair, P., Franz, C., Kahle, L., & Taylor, P.
Affiliations
  • National Institutes of Health (US)
  • National Cancer Institute (US)
Corresponding author
Dorgan, JF
ORCID
Kahle, L
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1996-12
Volume
64
Issue
6
Pages
850-855
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/64.6.850
OpenAlex
W2155838515
Cited by
181
References
42
Citations by year
2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 8 · 2013: 12 · 2012: 4
FWCI
2.40
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
dietary fat, dietary fiber, sex hormones, testosterone, estradiol, estrone, sex hormone-binding globulin, urinary excretion, men, low-fat diet, high-fat diet, polyunsaturated to saturated fat ratio
MeSH terms
Adult, Androgens, Body Weight, Cross-Sectional Studies, Dietary Fats, Dietary Fiber, Estradiol, Estrogens, Estrone, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone

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