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Cited by 140Iron Metabolism and DisordersTrace Elements in HealthInfant Nutrition and Health

The DOI matches its Crossref record; 41 of the 47 references it cites were found in a registry or an index.

Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy

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O’Brien, Kimberly O, Zavaleta, Nelly, Abrams, Steven A, Caulfield, Laura E·2003·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/77.4.924
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Abstract

Background The effect of maternal iron status on fetal iron deposition is uncertain.Objective We used a unique stable-isotope technique to assess iron transfer to the fetus in relation to maternal iron status.Design The study group comprised 41 Peruvian women. Of these women, 26 received daily prenatal supplements containing iron and folate (n = 11; Fe group) or iron, folate, and zinc (n = 15; Fe+Zn group) from week 10-24 of pregnancy to 1 mo postpartum. The remaining 15 women (control group) received iron supplementation only during the final month of pregnancy. During the third trimester of pregnancy (+/- SD: 32.9 +/- 1.4 wk gestation) oral 57Fe (10 mg) and intravenous 58Fe (0.6 mg) stable iron isotopes were administered to the women, and isotope enrichment and iron-status indicators were measured in cord blood at delivery.Results The net amount of 57Fe in the neonates' circulation (from maternal oral dosing) was significantly related to maternal iron absorption (P < 0.005) and inversely related to maternal iron status during the third trimester of pregnancy: serum ferritin (P < 0.0001), serum folate (P < 0.005), and serum transferrin receptors (P < 0.02). Significantly more 57Fe was transferred to the neonates in non-iron-supplemented women: 0.112 +/- 0.031 compared with 0.078 +/- 0.042 mg in the control group (n = 15) and the Fe and Fe+Zn groups (n = 24), respectively (P < 0.01). In contrast, 58Fe tracer in the neonates' circulation was not significantly related to maternal iron status.Conclusion The transfer of dietary iron to the fetus is regulated in response to maternal iron status at the level of the gut.

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  1. Sacco, 1999, Usual mineral intakes of Peruvian women during pregnancy, FASEB J, 13, A250

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Metadata

Authors
O’Brien, K. O., Zavaleta, N., Abrams, S. A., & Caulfield, L. E.
Affiliations
Agricultural Research Service (US)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2003-04
Volume
77
Issue
4
Pages
924-930
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/77.4.924
OpenAlex
W2155946656
Cited by
140
References
47
Citations by year
2026: 2 · 2025: 8 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 7 · 2018: 3 · 2017: 2 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 10
FWCI
3.80
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
maternal iron status, third trimester, iron supplementation, iron absorption, iron stable isotopes, serum ferritin, serum folate, transferrin receptor
MeSH terms
Adolescent, Adult, Diet, Female, Ferritins, Fetal Blood, Folic Acid, Gestational Age, Humans, Infant, Newborn, Iron, Iron Isotopes, Maternal-Fetal Exchange, Nutritional Status, Peru, Pregnancy, Pregnancy Trimester, Third, Zinc, Iron, Dietary, Dietary Supplements

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