The DOI matches its Crossref record.
Galactosylceramides in Human Plasma
Abstract
The purpose of this investigation was to establish levels of cerebrosides in human plasma as a guide in investigating cerebroside levels in destructive and demyelinating central nervous system disorders. As an increase in plasma galactosylceramide may accompany myelin breakdown, this test may serve as a means of monitoring diseases such as multiple sclerosis. Cerebrosides and lactosylceramides were analyzed in 50-ml. pooled plasma samples from patients with nonneurologic diseases. Particular attention was given to the determination of the proportions of galactosylceramide in the cerebroside fraction; the normal levels were 6–12%. Gas–liquid chromatography and mass spectrometry confirmed that this glycolipid was galactosylceramide and established the fatty acid composition. It was also confirmed that plasma cerebrosides consist of both glucosylceramide and galactosylceramide with normal and hydroxy fatty acids.
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“The CMH of human plasma was comprised of both glucosyl-(GlcCer) and galactosylceramides (GalCer), as has been reported before (27)(28)(29), with higher proportions of GlcCer.”
From Lipidomics reveals a remarkable diversity of lipids in human plasma (2010) · cites this paper as [27]
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Cited by
Lipidomics reveals a remarkable diversity of lipids in human plasma
Quehenberger, O., Armando, A. M., Brown, A. H., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S., Shaner, R. L., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009449 · Cited by 1,341
Metadata
- Authors
- Wells, H. W., & Jones, M.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-12-01
- Volume
- 60
- Issue
- 6
- Pages
- 890-896
- ISSN
- 0002-9173
- 1943-7722
- Cited by
- 7
- References
- 0
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
