The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Exposure to Drinking Water Disinfection By-Products and Pregnancy Loss
Abstract
Previous research has suggested that exposure to elevated levels of drinking water disinfection by-products (DBPs) may cause pregnancy loss. In 2000-2004, the authors conducted a study in three US locations of varying DBP levels and evaluated 2,409 women in early pregnancy to assess their tap water DBP concentrations, water use, other risk factors, and pregnancy outcome. Tap water concentrations were measured in the distribution system weekly or biweekly. The authors considered DBP concentration and ingested amount and, for trihalomethanes only, bathing/showering and integrated exposure that included ingestion. On the basis of 258 pregnancy losses, they did not find an increased risk of pregnancy loss in relation to trihalomethane, haloacetic acid, or total organic halide concentrations; ingested amounts; or total exposure. In contrast to a previous study, pregnancy loss was not associated with high personal trihalomethane exposure (> or =75 micro g/liter and > or =5 glasses of water/day) (odds ratio = 1.1, 95% confidence interval: 0.7, 1.7). Sporadic elevations in risk were found across DBPs, most notably for ingested total organic halide (odds ratio = 1.5, 95% confidence interval: 1.0, 2.2 for the highest exposure quintile). These results provide some assurance that drinking water DBPs in the range commonly encountered in the United States do not affect fetal survival.
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“A subsequent study conducted in North Carolina with a refined exposure characterization did not confirm these results [66].”
From Overview of Disinfection By-products and Associated Health Effects (2015) · cites this paper as [66]
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Cites
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AMERICAN PUBLIC HEALTH ASSOCIATION
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Self-citationTrihalomethanes in Drinking Water and Spontaneous Abortion
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Self-citationHousehold exposures to drinking water disinfection by-products: whole blood trihalomethane levels
Backer, L. C., Ashley, D. L., Bonin, M. A., Cardinali, F. L., Kieszak, S. M., & Wooten, J. V. (2000) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/sj.jea.7500098 · Cited by 159
Cited by
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Chlorination disinfection by-products, public health risk tradeoffs and me
Hrudey, S. E. (2009) · Water Research · doi:10.1016/j.watres.2009.02.011 · Cited by 465
Pan, Y., & Zhang, X. (2013) · Environmental Science & Technology · doi:10.1021/es303729n · Cited by 356
Environmental Exposures and Adverse Pregnancy Outcomes: A Review of the Science
Stillerman, K. P., Mattison, D. R., Giudice, L. C., & Woodruff, T. J. (2008) · Reproductive Sciences · doi:10.1177/1933719108322436 · Cited by 363
Overview of Disinfection By-products and Associated Health Effects
Villanueva, C. M., Cordier, S., Font-Ribera, L., Salas, L. A., & Levallois, P. (2015) · Current Environmental Health Reports · doi:10.1007/s40572-014-0032-x · Cited by 291
Toxic Impact of Bromide and Iodide on Drinking Water Disinfected with Chlorine or Chloramines
Yang, Y., Komaki, Y., Kimura, S. Y., Hu, H., Wagner, E. D., Mariñas, B. J., & Plewa, M. J. (2014) · Environmental Science & Technology · doi:10.1021/es503621e · Cited by 292
Metadata
- Authors
- Savitz, D. A., Singer, P. C., Herring, A. H., Hartmann, K. E., Weinberg, H. S., & Makarushka, C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-12
- Volume
- 164
- Issue
- 11
- Pages
- 1043-1051
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2098838722
- Semantic Scholar
- d69d10b9d7de3fb994cb89d97881e8adde48965e
- Cited by
- 177
- References
- 28
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 1 · 2020: 8 · 2019: 12 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 11
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Water Works Association Research Foundation
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- drinking water disinfection by-products, miscarriage, trihalomethanes, haloacetic acids, total organic halides, oral exposure, fetal survival, water distribution systems
- MeSH terms
- Abortion, Spontaneous, Adult, Data Interpretation, Statistical, Disinfectants, Environmental Exposure, Female, Humans, Hydrocarbons, Halogenated, Pregnancy, Pregnancy Outcome, Risk Factors, United States, Water Pollutants, Chemical, Water Supply, Water Purification, Trihalomethanes
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