Rotating Night Shift Work and the Risk of Ischemic Stroke
Open accessAbstract
Rotating night shift work disrupts circadian rhythms and is associated with coronary heart disease. The relation between rotating night shift work and ischemic stroke is unclear. The Nurses' Health Study, an ongoing cohort study of registered female nurses, assessed in 1988 the total number of years the nurses had worked rotating night shifts. The majority (69%) of stroke outcomes from 1988 to 2004 were confirmed by physician chart review. The authors used Cox proportional hazards models to assess the relation between years of rotating night shift work and ischemic stroke, adjusting for multiple vascular risk factors. Of 80,108 subjects available for analysis, 60% reported at least 1 year of rotating night shift work. There were 1,660 ischemic strokes. Rotating night shift work was associated with a 4% increased risk of ischemic stroke for every 5 years (hazard ratio = 1.04, 95% confidence interval: 1.01, 1.07; P(trend) = 0.01). This increase in risk was similar when limited to the 1,152 confirmed ischemic strokes (hazard ratio = 1.03, 95% confidence interval: 0.99, 1.07; P(trend) = 0.10) and may be confined to women with a history of 15 or more years of rotating shift work. Women appear to have a modestly increased risk of stroke after extended periods of rotating night shift work.
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Working night and rotating shifts is associated with elevated risk of heart disease and ischemic stroke.
“Working night shifts and rotating shifts has been associated with elevated risk of heart disease [76] and ischemic stroke [77,78].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [78]
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References 43 · Cited by 297
Research works printed but not linked: 1
- [39]39. Cox AM, McKevitt C, Rudd AG, et al. Socioeconomic status and stroke. Lancet Neurol . 2006;5(2):181-188.
- Authors
- Brown, D. L., Feskanich, D., Sanchez, B. N., Rexrode, K. M., Schernhammer, E. S., & Lisabeth, L. D.
- Affiliations
- Michigan Medicine (US)
- Harvard University (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-08
- Volume
- 169
- Issue
- 11
- Pages
- 1370-1377
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC2727250
- OpenAlex
- W2099565963
- Cited by
- 297
- References
- 43
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 16 · 2023: 24 · 2022: 25 · 2021: 19 · 2020: 18 · 2019: 17 · 2018: 19 · 2017: 21 · 2016: 18 · 2015: 18 · 2014: 18 · 2013: 17 · 2012: 23
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-088521, HL34594, R01HL034594, R01HL088521)
- National Cancer Institute (CA-87969, P01CA087969)
- National Institute of Neurological Disorders and Stroke (K23NS051202, K23NS050161)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Keywords
- rotating night shift work, ischemic stroke, circadian rhythm disruption, nurses, female nurses, occupational health, vascular risk factors, stroke risk
- MeSH terms
- Adult, Circadian Rhythm, Female, Humans, Longitudinal Studies, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, Sleep Wake Disorders, United States, Work Schedule Tolerance, Chi-Square Distribution, Likelihood Functions, Proportional Hazards Models, Stroke, White People
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