Cited by 147Influenza Virus Research StudiesRespiratory viral infections researchPneumonia and Respiratory Infections

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Age- and sex-related risk factors for influenza-associated mortality in the United States between 1997-2007

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Quandelacy, Talia M., Viboud, Cecile, Charu, Vivek, Lipsitch, Marc, Goldstein, Edward·2014·American Journal of Epidemiology

DOI 10.1093/aje/kwt235PMC PMC3873104

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Abstract

Limited information on age- and sex-specific estimates of influenza-associated death with different underlying causes is currently available. We regressed weekly age- and sex-specific US mortality outcomes underlying several causes between 1997 and 2007 to incidence proxies for influenza A/H3N2, A/H1N1, and B that combine data on influenza-like illness consultations and respiratory specimen testing, adjusting for seasonal baselines and time trends. Adults older than 75 years of age had the highest average annual rate of influenza-associated mortality, with 141.15 deaths per 100,000 people (95% confidence interval (CI): 118.3, 163.9), whereas children under 18 had the lowest average mortality rate, with 0.41 deaths per 100,000 people (95% CI: 0.23, 0.60). In addition to respiratory and circulatory causes, mortality with underlying cancer, diabetes, renal disease, and Alzheimer disease had a contribution from influenza in adult age groups, whereas mortality with underlying septicemia had a contribution from influenza in children. For adults, within several age groups and for several underlying causes, the rate of influenza-associated mortality was somewhat higher in men than in women. Of note, in men 50-64 years of age, our estimate for the average annual rate of influenza-associated cancer mortality per 100,000 persons (1.90, 95% CI: 1.20, 2.62) is similar to the corresponding rate of influenza-associated respiratory deaths (1.81, 95% CI: 1.42, 2.21). Age, sex, and underlying health conditions should be considered when planning influenza vaccination and treatment strategies.

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Authors: Quandelacy, T. M., Viboud, C., Charu, V., Lipsitch, M., & Goldstein, E.
Affiliations: Harvard University (US)
Corresponding author: Goldstein, Edward
ORCID: Viboud, Cecile
Charu, Vivek
Lipsitch, Marc
Goldstein, Edward
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2013-11-04
Volume: 179
Issue: 2
Pages: 156-167
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/kwt235
PMC: PMC3873104
OpenAlex: W2144402463
Semantic Scholar: b13ae7df58f22e0addb72022d1045095838faca0
Cited by: 144
References: 34
Citations by year: 2026: 3 · 2025: 8 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 10 · 2017: 14 · 2016: 9 · 2015: 13 · 2014: 5 · 2013: 1
FWCI: 6.80
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Epidemiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
Johns Hopkins University
National Institutes of Health
School of Medicine, Johns Hopkins University
National Institute of General Medical Sciences (U54GM088558, T32GM007309, award number U54GM088558)
National Institute of Allergy and Infectious Diseases (K01AI101010)
Fogarty International Center
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Keywords: influenza-associated deaths, age-specific mortality, sex differences, H3N2, H1N1 influenza, influenza B, influenza-like illness, underlying cause of death, cancer mortality, respiratory mortality, septicemia, children, older adults
MeSH terms: Adolescent, Adult, Age Factors, Aged, Child, Female, Humans, Influenza, Human, Male, Middle Aged, Pneumonia, Risk Factors, Sex Factors, United States, Alphainfluenzavirus, Betainfluenzavirus, Young Adult

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Age- and sex-related risk factors for influenza-associated mortality in the United States between 1997-2007

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