Physical Activity Types and Coronary Heart Disease Risk in Middle-Aged and Elderly Persons: The Rotterdam Study
Abstract
Physical activity is associated with decreased risk of coronary heart disease (CHD). The specific physical activity types that provide beneficial effects in an older population remain unclear. We assessed the association of total physical activity, walking, cycling, domestic work, sports, and gardening with CHD by using Cox proportional hazard models among 5,901 participants aged >55 (median age, 67) years from the prospective population-based Rotterdam Study, enrolled between 1997 and 2001. Activities were categorized into tertiles, and the lowest tertiles were used as reference. In the multivariable model, we adjusted for age, sex, smoking, alcohol consumption, education, diet, and other physical activity types. During 15 years of follow-up (median, 10.3 (interquartile range, 8.0-11.8) years), 642 participants (10.9%) experienced a CHD event. In the multivariable model, the respective hazard ratios for the medium and high categories compared with the low category were 0.79 (95% confidence interval CI): 0.66, 0.96) and 0.71 (95% CI: 0.58, 0.87) for total physical activity, 0.76 (95% CI: 0.63, 0.92) and 0.70 (95% CI: 0.57, 0.88) for cycling, and 0.81 (95% CI: 0.66, 0.98) and 0.71 (95% CI: 0.56, 0.90) for domestic work. Walking, sports, and gardening were not associated with CHD. In conclusion, in this long-term follow-up study of older adults, domestic work and cycling were associated with reduced CHD risk. Physical activity should be promoted in this population with the aim…
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Increased cardiorespiratory fitness is associated with a progressive reduction of cardiovascular events.
“Increased cardiorespiratory fitness is associated with a progressive reduction of cardiovascular events, which would seem to be at odds with the aforementioned link between lifelong exercise load and increased coronary atherosclerosis.”
From Lifelong endurance exercise and its relation with coronary atherosclerosis (2023) · cites this paper as [9]
Regular exercise improves blood pressure control and lipid profiles, reduces the incidence of diabetes and myocardial infarction, and increases life expectancy.
“Regular exercise improves blood pressure control and lipid profiles, reduces the incidence of diabetes and myocardial infarction, and increases life expectancy.6–9”
From Lifelong endurance exercise and its relation with coronary atherosclerosis (2023) · cites this paper as [9]
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Lifelong endurance exercise and its relation with coronary atherosclerosis
De Bosscher, R., Dausin, C., Claus, P., Bogaert, J., Dymarkowski, S., Goetschalckx, K., Ghekiere, O., Van De Heyning, C. M., Van Herck, P., Paelinck, B., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad152 · Cited by 140 · see citing works
Physical activity and cause-specific mortality: the Rotterdam Study
Koolhaas, C. M., Dhana, K., Schoufour, J. D., Lahousse, L., van Rooij, F. J. A., Ikram, M. A., Brusselle, G., Tiemeier, H., & Franco, O. H. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy058 · Cited by 33 · see citing works
Self-citation
- Authors
- Koolhaas, C. M., Dhana, K., Golubic, R., Schoufour, J. D., Hofman, A., van Rooij, F. J. A., & Franco, O. H.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Koolhaas, Chantal M.
- Franco, Oscar H.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-28
- Volume
- 183
- Issue
- 8
- Pages
- 729-738
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2322742466
- Cited by
- 60
- References
- 7
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 13 · 2017: 5 · 2016: 5
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Erasmus MC and Erasmus University, Rotterdam, the Netherlands
- the Netherlands Organization for Scientific Research (NWO)
- the Netherlands Organization for Health Research and Development (ZonMw)
- the Research Institute for Diseases in the Elderly (RIDE)
- the Ministry of Education, Culture, and Science
- the Ministry for Health, Welfare, and Sports
- the European Commission (DG XII)
- Municipality of Rotterdam
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- physical activity, coronary artery disease, middle-aged and older adults, cycling, domestic work, walking, sport, gardening, cardiovascular risk, Rotterdam Study
- MeSH terms
- Aged, Bicycling, Coronary Artery Disease, Household Work, Humans, Male, Middle Aged, Netherlands, Prospective Studies, Surveys and Questionnaires, Risk Factors, Sports, Time Factors, Exercise, Multivariate Analysis, Proportional Hazards Models, Walking, Gardening, Protective Factors
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