Impact of Spironolactone on Vascular, Myocardial, and Functional Parameters in Untreated Patients With a Hypertensive Response to Exercise

Hare, J. L.; Sharman, J. E.; Leano, R.; Jenkins, C.; Wright, L.; Marwick, T. H.

doi:10.1093/ajh/hpt008

Impact of Spironolactone on Vascular, Myocardial, and Functional Parameters in Untreated Patients With a Hypertensive Response to Exercise

Background Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. Methods In thi…