ROSIGLITAZONE RELIEVES ACUTE ETHANOL-INDUCED HANGOVER IN SPRAGUE–DAWLEY RATS
Open accessAbstract
AIMS: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. METHODS: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis. RESULTS: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. CONCLUSIONS: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.
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Swedish men did not show any evidence of gaining weight with night time meals.
“Swedish men did not show any evidence of gaining weight with night time meals.23”
From Festive medical myths (2008) · cites this paper as [23]
Other studies found no link at all between eating at night and weight gain.
“Other studies found no link at all between eating at night and weight gain.”
From Festive medical myths (2008) · cites this paper as [23]
In a study of 86 obese and 61 normal weight men, there were no differences in the timing of when they ate.
“In a study of 86 obese and 61 normal weight men, there were no differences in the timing of when they ate.23”
From Festive medical myths (2008) · cites this paper as [23]
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Vreeman, R. C., & Carroll, A. E. (2008) · BMJ · doi:10.1136/bmj.a2769 · Cited by 11 · see citing works
- Authors
- JUNG, T. W., LEE, J. Y., SHIM, W. S., KANG, E. S., KIM, S. K., AHN, C. W., LEE, H. C., & CHA, B. S.
- Affiliations
- Yonsei University (KR)
- CHA University (KR)
- Corresponding author
- JUNG, TAE WOO
- Venue
- Alcohol and Alcoholism
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-22
- Volume
- 41
- Issue
- 3
- Pages
- 231-235
- ISSN
- 0735-0414 (ISSN-L)
- 1464-3502
- OpenAlex
- W2155864907
- Cited by
- 15
- References
- 0
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alcohol and Alcoholism (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- rosiglitazone, ALDH2, acetaldehyde detoxification, PPARγ agonists, cyanamide, social interaction behavior
- MeSH terms
- Rosiglitazone, Ethanol, Animals, Central Nervous System Depressants, Cyanamide, Hypoglycemic Agents, Interpersonal Relations, Male, Mitochondria, Liver, Social Behavior, Immunoblotting, Blotting, Western, Up-Regulation, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Thiazolidinediones, Rats
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