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Inferring gene networks from time series microarray data using dynamic Bayesian networks
Open accessAbstract
Dynamic Bayesian networks (DBNs) are considered as a promising model for inferring gene networks from time series microarray data. DBNs have overtaken Bayesian networks (BNs) as DBNs can construct cyclic regulations using time delay information. In this paper, a general framework for DBN modelling is outlined. Both discrete and continuous DBN models are constructed systematically and criteria for learning network structures are introduced from a Bayesian statistical viewpoint. This paper reviews the applications of DBNs over the past years. Real data applications for Saccharomyces cerevisiae time series gene expression data are also shown.
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“Unlike BNs, DBNs can include cycles and may be constructed when time-course data are available [89–92].”
From Reverse engineering and identification in systems biology: strategies, perspectives and challenges (2014) · cites this paper as [90]
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Metadata
- Authors
- Kim, S. Y.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Kim, S. Y.
- Venue
- Briefings in Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 4
- Issue
- 3
- Pages
- 228-235
- ISSN
- 1467-5463 (ISSN-L)
- 1477-4054
- OpenAlex
- W2108579152
- Cited by
- 308
- References
- 17
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 2 · 2023: 13 · 2022: 2 · 2021: 10 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 16 · 2014: 20 · 2013: 16 · 2012: 22
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Briefings in Bioinformatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Physical Sciences › Computer Science › Artificial Intelligence › Bayesian Modeling and Causal Inference
- Keywords
- dynamic Bayesian networks, gene regulatory network inference, time series microarray data, time delay, network structure learning, Bayesian network structure learning, Saccharomyces cerevisiae, gene expression time series
- MeSH terms
- Algorithms, Bayes Theorem, Computer Simulation, Mathematics, Models, Genetic, Saccharomyces cerevisiae, Time Factors, Gene Expression Regulation, Fungal, Computational Biology, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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