The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Toward the dynamic interactome: it's about time
Open accessAbstract
Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.
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Citations
Cites
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Cited by
Holme, P., & Saramäki, J. (2012) · Physics Reports · doi:10.1016/j.physrep.2012.03.001 · Cited by 2,736
“[48] believe that a ‘‘shift from static to dynamic network analysis is essential for further understanding’’ of the interactome.”
BackgroundTopological analysis and interactive visualization of biological networks and protein structures
Doncheva, N. T., Assenov, Y., Domingues, F. S., & Albrecht, M. (2012) · Nature Protocols · doi:10.1038/nprot.2012.004 · Cited by 503
Gaiteri, C., Ding, Y., French, B., Tseng, G. C., & Sibille, E. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12106 · Cited by 289
Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases
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Petukh, M., Li, M., & Alexov, E. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004276 · Cited by 107
Metadata
- Authors
- Przytycka, T. M., Singh, M., & Slonim, D. K.
- Venue
- Briefings in Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01-01
- Volume
- 11
- Issue
- 1
- Pages
- 15-29
- ISSN
- 1467-5463 (ISSN-L)
- 1477-4054
- OpenAlex
- W2162032011
- Cited by
- 254
- References
- 21
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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