A broken promise: microbiome differential abundance methods do not control the false discovery rate

Hawinkel, Stijn, Mattiello, Federico, Bijnens, Luc, Thas, Olivier·2019·Briefings in Bioinformatics

Cited by (200)

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  10. Impact of data compositionality on the detection of microbiota responses
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  13. A realistic benchmark for the identification of differentially abundant taxa in (confounded) human microbiome studies
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  15. Simple and flexible sign and rank-based methods for testing for differential abundance in microbiome studies
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  18. Some comments on certain statistical aspects of the study of the microbiome
    José A. Ferreira, Susana Fuentes · 2019 · Briefings in Bioinformatics
  19. Testing hypotheses about the microbiome using the linear decomposition model (LDM)
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  20. The gut microbiota in spondyloarthritis: an update
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  21. Taxonomy and Virulence Factors in the Root Canal Microbiome: Metagenomic Insights by Lesion Size and Clinical Factors in Primary Endodontic Infections
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  22. Composition and functionality of bacterioplankton communities in marine coastal zones adjacent to finfish aquaculture
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  25. A reproducible effect size is more useful than an irreproducible hypothesis test to analyze high throughput sequencing datasets
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  26. The Role of Environmental and Climatic Factors in Accelerating Antibiotic Resistance in the Mediterranean Region
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  29. Molecular and associated approaches for studying soil biota and their functioning
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  30. ProgPerm: Progressive permutation for a dynamic representation of the robustness of microbiome discoveries
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  31. Correlation analysis of the oral mucosal microbiome and diabetes mellitus using microbial DNA in elderly male subjects
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  33. llperm: a permutation of regressor residuals test for microbiome data
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  34. The Influence of the Degree of Forest Management on Methylmercury and the Composition of Microbial Communities in the Sediments of Boreal Drainage Ditches
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  40. Compositional Differential Abundance Testing: Defining and Finding a New Type of Health-Microbiome Associations
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  44. The relationship between the gut microbiota and neuropsychological development and behaviour during childhood and adolescence: a systematic review of epidemiological studies
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  45. Compositional Analysis of Microbiome Data
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  46. A semiparametric quantile regression rank score test for zero-inflated data
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  47. A resampling-based empirical Bayes method for precise false discovery rate estimation under dependence
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  48. Group Heteroscedasticity - A Silent Saboteur of Power and False Discovery in RNA-Seq Differential Expression
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  49. Not every gene is special: one simple rule to control the false discovery rate when analysing high-throughput sequencing data
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  50. Microbial community profiling of human gastrointestinal cancers
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  51. ProgPermute: Progressive permutation for a dynamic representation of the robustness of microbiome discoveries
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  52. Analysing microbiome intervention studies: Does choice of a statistical method affect biological interpretation?
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  53. Analysing microbiome intervention studies: Does choice of a statistical method affect biological interpretation?
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  54. Analysing microbiome intervention studies: Does choice of a statistical method affect biological interpretation?
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  57. Pairwise ratio-based differential abundance analysis of infant microbiome 16S sequencing data
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  60. Additional file 2 of Clipper: p-value-free FDR control on high-throughput data from two conditions
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  62. Network based differential abundance analysis: bridging community interactions and host microbiome dynamics
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  65. Additional file 2 of A comprehensive evaluation of microbial differential abundance analysis methods: current status and potential solutions
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  66. Additional file 8 of mbImpute: an accurate and robust imputation method for microbiome data
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  67. Additional file 3 of A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies
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  68. Additional file 4 of A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies
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  69. Additional file 2 of A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies
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  70. Additional file 1 of Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox
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  71. Additional file 1 of LinDA: linear models for differential abundance analysis of microbiome compositional data
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  72. Additional file 1 of mbImpute: an accurate and robust imputation method for microbiome data
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  73. Additional file 1 of Metatranscriptomic analyses reveal ruminal pH regulates fiber degradation and fermentation by shifting the microbial community and gene expression of carbohydrate-active enzymes
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  74. Additional file 1 of Relative abundance data can misrepresent heritability of the microbiome
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  75. Additional file 3 of LinDA: linear models for differential abundance analysis of microbiome compositional data
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  76. Additional file 1 of A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies
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  77. Additional file 10 of Comparison study of differential abundance testing methods using two large Parkinson disease gut microbiome datasets derived from 16S amplicon sequencing
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  78. Additional file 1 of Randomized quantile residuals for diagnosing zero-inflated generalized linear mixed models with applications to microbiome count data
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  79. Additional file 2 of LinDA: linear models for differential abundance analysis of microbiome compositional data
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  80. Additional file 2 of Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox
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  81. Additional file 1 of Clipper: p-value-free FDR control on high-throughput data from two conditions
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  82. Additional file 1 of ProgPerm: Progressive permutation for a dynamic representation of the robustness of microbiome discoveries
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  83. Additional file 11 of Comparison study of differential abundance testing methods using two large Parkinson disease gut microbiome datasets derived from 16S amplicon sequencing
    Wallen, Zachary D. · 2021 · Figshare
  84. Additional file 1 of Accommodating multiple potential normalizations in microbiome associations studies
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  85. Additional file 1 of Powerful and robust non-parametric association testing for microbiome data via a zero-inflated quantile approach (ZINQ)
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  86. Additional file 1 of PhyloMed: a phylogeny-based test of mediation effect in microbiome
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  87. Additional file 3 of Clipper: p-value-free FDR control on high-throughput data from two conditions
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  88. Additional file 3 of Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox
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  89. Additional file 2 of PhyloMed: a phylogeny-based test of mediation effect in microbiome
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