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Cited by 265

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Rose: generating sequence families.

Open access
Stoye, J, Evers, D, Meyer, F·1998·Bioinformatics

Abstract

MOTIVATION: We present a new probabilistic model of the evolution of RNA-, DNA-, or protein-like sequences and a software tool, Rose, that implements this model. Guided by an evolutionary tree, a family of related sequences is created from a common ancestor sequence by insertion, deletion and substitution of characters. During this artificial evolutionary process, the 'true' history is logged and the 'correct' multiple sequence alignment is created simultaneously. The model also allows for varying rates of mutation within the sequences, making it possible to establish so-called sequence motifs. RESULTS: The data created by Rose are suitable for the evaluation of methods in multiple sequence alignment computation and the prediction of phylogenetic relationships. It can also be useful when teaching courses in or developing models of sequence evolution and in the study of evolutionary processes. AVAILABILITY: Rose is available on the Bielefeld Bioinformatics WebServer under the following URL: http://bibiserv.TechFak.Uni-Bielefeld.DE/rose/ The source code is available upon request. Contact: folker@TechFak.Uni-Bielefeld.DE

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Metadata

Authors
Stoye, J., Evers, D., & Meyer, F.
Venue
Bioinformatics
Published
1998-01-01
Volume
14
Issue
2
Pages
157-163
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2097386339
Cited by
265
References
4
FWCI
0.45
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Rose: generating sequence families. https://app.cochat.ai/papers/10.1093/bioinformatics/14.2.157
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Stoye, J., Evers, D., & Meyer, F. (1998). Rose: generating sequence families. Bioinformatics. https://doi.org/10.1093/bioinformatics/14.2.157

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