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Cited by 358

The DOI matches its Crossref record.

DIALIGN: finding local similarities by multiple sequence alignment.

Open access
Morgenstern, B, Frech, K, Dress, A, Werner, T·1998·Bioinformatics
DOI 10.1093/bioinformatics/14.3.290
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Abstract

MOTIVATION: DIALIGN is a new method for pairwise as well as multiple alignment of nucleic acid and protein sequences. While standard alignment programs rely on comparing single residues and imposing gap penalties, DIALIGN constructs alignments by comparing whole segments of the sequences. No gap penalty is employed. This point of view is especially adequate if sequences are not globally related, but share only local similarities, as is the case in genomic DNA sequences and in many protein families. RESULTS: Using four different data sets, we show that DIALIGN is able correctly to align conserved motifs in protein sequences. Alignments produced by DIALIGN are compared systematically to the results of five other alignment programs. AVAILABILITY: DIALIGN is available to the scientific community free of charge for non-commercial use. Executables for various UNIX platforms including LINUX can be downloaded at http://www.gsf.de/biodv/dialign.html Contact: werner, morgenstern@gsf.de

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Metadata

Authors
Morgenstern, B., Frech, K., Dress, A., & Werner, T.
Venue
Bioinformatics
Publisher
Oxford University Press (OUP)
Published
1998-01-01
Volume
14
Issue
3
Pages
290-294
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
DOI
10.1093/bioinformatics/14.3.290
OpenAlex
W2036295979
Cited by
358
References
0
FWCI
2.93
Type
journal article
Language
en
Open access
bronze

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