Humanization of antibodies using a machine learning approach on large-scale repertoire data

Marks, Claire, Hummer, Alissa M, Chin, Mark, Deane, Charlotte M·2021·Bioinformatics
DOI 10.1093/bioinformatics/btab434

Cited by (123)

Items 101–123 of 123

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  4. Novel Bio-Engineering Techniques for Construction of Next-Generation Monoclonal Antibodies in the Framework of Personalized Medicine
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  5. AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve Efficacy
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  8. Are frameworks independent from CDRs in antibodies? Exploring CDR-framework correlation networks of antibodies
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  9. Sourcing and screening human antibody repertoires for discovering biotherapeutics
    Yasmina Noubia Abdiche, René Hoet · 2025 · Elsevier eBooks
  10. Rational Immunogenicity Modulation of Virus-Like Particles by VLPIM
    Chufan Wang, Yeyun Chen, Mengdi Wang, Lei Ren, Qingtong Zhou · 2026 · Computational and Structural Biotechnology Journal
  11. Explicit representation of germline and non-germline residues improves antibody language modeling
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  12. Complementarity of Deep Learning and Physics-Based Approaches in the Design of New Antibodies
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  13. Development of a TME-responsive humanised scFv fragment-drug conjugate targeting KRAS G12V colorectal cancer
    Jung Yin Fong, Yu Shyan Low, Jeremy Jeack Ceen Ng, Hok Chai Yam, Allan Wee Ren Ng, Chun‐Wai Mai, Michelle Yee Mun Teo, Lionel Lian Aun In · 2026 · Journal of Drug Delivery Science and Technology
  14. Multi-objective antibody design and optimization using machine learning
    Yun‐Huai Kuo, Chloe N. Brown, Ece Akin, Yunxuan Xie, Peter M. Tessier · 2026 · Nature Reviews Bioengineering
  15. Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains
    Alexander Kinna, Preeta Datta, Reyisa Bughda, Farhaan Parekh, Mathew P. Robson, Ram Jha, Phillip Wu, Ian Scott, Elizabeth Hogben, Oliver Amin et al. · 2026 · Molecular Therapy
  16. AI-Driven Design Platforms of Next-Generation Antibody Therapeutics
    Yue Wang, Afsheen Saba, Yue Ran, Kiran Shehzadi, Q Zhang, Liang Jianhua, Mingjia Yu · 2026 · Topics in Current Chemistry
  17. The immunogenicity database collaborative: a standardized, publicly available database for clinical immunogenicity observations and insights
    Sudhanshu Agnihotri, Bruno Gonzalez-Nolasco, Brinda Monian, Sofie Pattijn, Chloé Ackaert, Patrick Wu, Hubert Kettenberger, Sophie Tourdot, Timothy Paul Hickling, Zicheng Hu et al. · 2026 · Frontiers in Immunology
  18. Clinical MAPPs: a personalized healthcare-driven assay for the direct identification of potential T cell epitopes in patients
    Katharina Hartman, Guido Steiner, Cary M. Looney, Michel Siegel, Katharine M. Bray, Klaudia Brix, Sebastian Springer, Timothy Paul Hickling, Niels Janssen, Axel Ducret et al. · 2026 · Frontiers in Immunology
  19. An experimentally validated structure-based computational framework for humanisation of anti-orthopoxvirus antibodies
    Xuehua Yang, Xuemeng Dong, Jiahan Lu, Xiaojing Chi, Xiuying Liu, Huarui Duan, Peixiang Gao, Jing Xue, Wei Zhong Yang · 2026 · EBioMedicine
  20. Beyond affinity: AI-supported developability assessment and multi-objective optimization in antibody development
    Qianhui Jiang, Jiahui Guan, Dan Yu, Pradeep Singh, George Pelekos, Edward Chin Man Lo, Junwen Wang · 2026 · Antibody Therapeutics
  21. The Evolution of Artificial Intelligence in Antibody Design: From Structure-Based Engineering to Generative Models
    Ida Szataniak, Kacper Packi · 2026 · Antibodies
  22. Computational design and translational development of TCR-mimic scFv antibodies for peptide-HLA neoantigen targeting
    Sarfaraz K. Niazi, Matthias Magoola, Zamara Mariam · 2026 · npj Drug Discovery.
  23. OAS-nano: the Observed VHH Space Database
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