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PMUT: a web-based tool for the annotation of pathological mutations on proteins
Open accessAbstract
Summary: PMUT allows the fast and accurate prediction (~80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server. Availability: PMUT is freely accessible at http://mmb2.pcb.ub.es:8080/PMut/ Contact: [email protected] Supplementary information: http://mmb2.pcb.ub.es:8080/PMutWeb/methodology.html
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Cited by
Kumar, P., Henikoff, S., & Ng, P. C. (2009) · Nature Protocols · doi:10.1038/nprot.2009.86 · Cited by 6,521
MutationTaster evaluates disease-causing potential of sequence alterations
Schwarz, J. M., Rödelsperger, C., Schuelke, M., & Seelow, D. (2010) · Nature Methods · doi:10.1038/nmeth0810-575 · Cited by 2,975
Leber congenital amaurosis: Genes, proteins and disease mechanisms
den Hollander, A. I., Roepman, R., Koenekoop, R. K., & Cremers, F. P. M. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.003 · Cited by 811
<emph type="ital">SQSTM1</emph> Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Fecto, F. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.250 · Cited by 650
Performance of mutation pathogenicity prediction methods on missense variants
Thusberg, J., Olatubosun, A., & Vihinen, M. (2011) · Human Mutation · doi:10.1002/humu.21445 · Cited by 537
Metadata
- Authors
- Ferrer-Costa, C., Gelpi, J. L., Zamakola, L., Parraga, I., de la Cruz, X., & Orozco, M.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-06
- Volume
- 21
- Issue
- 14
- Pages
- 3176-3178
- ISSN
- 0266-7061 (ISSN-L)
- 1367-4803
- 1460-2059
- OpenAlex
- W2123943285
- Cited by
- 496
- References
- 0
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ferrer-Costa, C., Gelpi, J. L., Zamakola, L., Parraga, I., de la Cruz, X., & Orozco, M. (2005). PMUT: a web-based tool for the annotation of pathological mutations on proteins. Bioinformatics. https://doi.org/10.1093/bioinformatics/bti486
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