The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
GenABEL: an R library for genome-wide association analysis
Abstract
Here we describe an R library for genome-wide association (GWA) analysis. It implements effective storage and handling of GWA data, fast procedures for genetic data quality control, testing of association of single nucleotide polymorphisms with binary or quantitative traits, visualization of results and also provides easy interfaces to standard statistical and graphical procedures implemented in base R and special R libraries for genetic analysis. We evaluated GenABEL using one simulated and two real data sets. We conclude that GenABEL enables the analysis of GWA data on desktop computers. Availability: http://cran.r-project.org Contact: i.aoultchenko@erasmusmc.nl
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“The genomic inflation factor lambda was computed with the GenABEL 1.8-0 R package63 and a median approach after exclusion of the APOE region (44–46 Mb on chromosome 19 in GRCh38).”
From New insights into the genetic etiology of Alzheimer’s disease and related dementias (2022) · cites this paper as [63]
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Cites
Generating samples under a Wright–Fisher neutral model of genetic variation
Hudson, R. R. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.2.337 · Cited by 2,397
Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous
Schaid, D. J., Rowland, C. M., Tines, D. E., Jacobson, R. M., & Poland, G. A. (2002) · The American Journal of Human Genetics · doi:10.1086/338688 · Cited by 1,777
A Note on Exact Tests of Hardy-Weinberg Equilibrium
Wigginton, J. E., Cutler, D. J., & Abecasis, G. R. (2005) · The American Journal of Human Genetics · doi:10.1086/429864 · Cited by 1,492
Genome-wide association: a promising start to a long race
Evans, D. M., & Cardon, L. R. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.05.001 · Cited by 33
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GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279
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Zhou, X., & Stephens, M. (2012) · Nature Genetics · doi:10.1038/ng.2310 · Cited by 3,627
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Wright, M. N., & Ziegler, A. (2017) · Journal of Statistical Software · doi:10.18637/jss.v077.i01 · Cited by 4,185
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946
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Jombart, T., & Ahmed, I. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr521 · Cited by 3,233
Metadata
- Authors
- Aulchenko, Y. S., Ripke, S., Isaacs, A., & van Duijn, C. M.
- Affiliations
- Erasmus MC (NL)
- 1 Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands and 2Statistical Genetics Group, Max-Planck-Institute of Psychiatry, Kraepelinstr. 10, D-80804 Munich, Germany
- Corresponding author
- Aulchenko, Yurii S.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03-23
- Volume
- 23
- Issue
- 10
- Pages
- 1294-1296
- ISSN
- 1367-4803 (ISSN-L)
- 1367-4811
- OpenAlex
- W2161245845
- Cited by
- 1,836
- References
- 4
- Citations by year
- 2026: 22 · 2025: 39 · 2024: 91 · 2023: 72 · 2022: 65 · 2021: 129 · 2020: 113 · 2019: 161 · 2018: 178 · 2017: 153 · 2016: 139 · 2015: 143 · 2014: 140 · 2013: 116 · 2012: 89
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioinformatics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- genome-wide association study, R library, single nucleotide polymorphisms, association testing, binary traits, quantitative traits, statistical software
- MeSH terms
- Computer Simulation, Haplotypes, Humans, Software, Gene Library, Genome, Human, Information Storage and Retrieval, Genome, Computational Biology, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide
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