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ART: a next-generation sequencing read simulator

Open access
Huang, Weichun, Li, Leping, Myers, Jason R., Marth, Gabor T.·2012·Bioinformatics

Abstract

Summary: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles. Availability: Both source and binary software packages are available at http://www.niehs.nih.gov/research/resources/software/art Contact: weichun.huang@nih.gov; gabor.marth@bc.edu Supplementary information: Supplementary data are available at Bioinformatics online.

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Metadata

Authors
Huang, W., Li, L., Myers, J. R., & Marth, G. T.
Venue
Bioinformatics
Published
2011-12-23
Volume
28
Issue
4
Pages
593-594
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2157539385
Cited by
1,596
References
2
FWCI
11.76
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: ART: a next-generation sequencing read simulator. https://app.cochat.ai/papers/10.1093/bioinformatics/btr708
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Huang, W., Li, L., Myers, J. R., & Marth, G. T. (2012). ART: a next-generation sequencing read simulator. Bioinformatics. https://doi.org/10.1093/bioinformatics/btr708

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