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nhmmer: DNA homology search with profile HMMs

Open access
Wheeler, Travis J., Eddy, Sean R.·2013·Bioinformatics

Abstract

Summary: Sequence database searches are an essential part of molecular biology, providing information about the function and evolutionary history of proteins, RNA molecules and DNA sequence elements. We present a tool for DNA/DNA sequence comparison that is built on the HMMER framework, which applies probabilistic inference methods based on hidden Markov models to the problem of homology search. This tool, called nhmmer, enables improved detection of remote DNA homologs, and has been used in combination with Dfam and RepeatMasker to improve annotation of transposable elements in the human genome. Availability: nhmmer is a part of the new HMMER3.1 release. Source code and documentation can be downloaded from http://hmmer.org. HMMER3.1 is freely licensed under the GNU GPLv3 and should be portable to any POSIX-compliant operating system, including Linux and Mac OS/X. Contact: wheelert@janelia.hhmi.org

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Metadata

Authors
Wheeler, T. J., & Eddy, S. R.
Venue
Bioinformatics
Published
2013-07-09
Volume
29
Issue
19
Pages
2487-2489
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2154775341
Cited by
926
References
8
FWCI
6.86
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: nhmmer: DNA homology search with profile HMMs. https://app.cochat.ai/papers/10.1093/bioinformatics/btt403
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Wheeler, T. J., & Eddy, S. R. (2013). nhmmer: DNA homology search with profile HMMs. Bioinformatics. https://doi.org/10.1093/bioinformatics/btt403

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