The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
An integrative approach to predicting the functional effects of non-coding and coding sequence variation
Open accessAbstract
Motivation: Technological advances have enabled the identification of an increasingly large spectrum of single nucleotide variants within the human genome, many of which may be associated with monogenic disease or complex traits. Here, we propose an integrative approach, named FATHMM-MKL, to predict the functional consequences of both coding and non-coding sequence variants. Our method utilizes various genomic annotations, which have recently become available, and learns to weight the significance of each component annotation source. Results: We show that our method outperforms current state-of-the-art algorithms, CADD and GWAVA, when predicting the functional consequences of non-coding variants. In addition, FATHMM-MKL is comparable to the best of these algorithms when predicting the impact of coding variants. The method includes a confidence measure to rank order predictions. Availability and implementation: The FATHMM-MKL webserver is available at: http://fathmm.biocompute.org.uk Contact: H.Shihab@bristol.ac.uk or Mark.Rogers@bristol.ac.uk or C.Campbell@bristol.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
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Forbes, S. A., Beare, D., Boutselakis, H., Bamford, S., Bindal, N., Tate, J., Cole, C. G., Ward, S., Dawson, E., Ponting, L., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1121 · Cited by 1,922
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Liu, X., Li, C., Mou, C., Dong, Y., & Tu, Y. (2020) · Genome Medicine · doi:10.1186/s13073-020-00803-9 · Cited by 657
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Metadata
- Authors
- Shihab, H. A., Rogers, M. F., Gough, J., Mort, M., Cooper, D. N., Day, I. N. M., Gaunt, T. R., & Campbell, C.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-02-11
- Volume
- 31
- Issue
- 10
- Pages
- 1536-1543
- ISSN
- 1367-4803 (ISSN-L)
- 1367-4811
- OpenAlex
- W2148105023
- Cited by
- 697
- References
- 20
- FWCI
- 29.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shihab, H. A., Rogers, M. F., Gough, J., Mort, M., Cooper, D. N., Day, I. N. M., Gaunt, T. R., & Campbell, C. (2015). An integrative approach to predicting the functional effects of non-coding and coding sequence variation. Bioinformatics. https://doi.org/10.1093/bioinformatics/btv009
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