Diabetic control and nutritional status up to 1 year after total pancreatectomy: a nationwide multicentre prospective study

Abstract

Dear Editor Total pancreatectomy is increasingly performed worldwide with aftercare using newly developed insulin products and high-titre pancrelipase1–4. Furthermore, recent advances in diagnostic modalities have led to an increase in the number of patients diagnosed with existing lesions in the remnant pancreas during follow-up after initial pancreatectomy5. However, current data on diabetes management and nutritional status following total pancreatectomy from large nationwide series remain lacking, and the differences between one-stage total pancreatectomy and completion pancreatectomy are not known. The aim of this study was to assess glycaemic control and nutritional status after total pancreatectomy. In a prospective nationwide multicentre study, data were assessed for 216 consecutive patients who underwent total pancreatectomy, including one-stage total pancreatectomy and completion pancreatectomy, between August 2015 and December 2017 in 68 Japanese centres (Trial registration UMIN-CTR #UMIN000018763). Of the 216 patients, 180 patients with a follow-up period of 1 year were included in the study. Changes in glycaemic control and nutritional status within a year after surgery were investigated, in addition to the differences between one-stage total pancreatectomy (106 patients) and completion pancreatectomy (74 patients). Data were collected at 1, 3, 6 and 12 months after surgery (postoperative month (POM) 1, 3, 6, and 12) during the follow-up period. Clinicopathologic…