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DUCHENNE MUSCULAR DYSTROPHY: PLASMA MEMBRANE LOSS INITIATES MUSCLE CELL NECROSIS UNLESS IT IS REPAIRED
Abstract
Study of biopsies from 30 boys with Duchenne muscular dystrophy suggests that necrosis of muscle cells is initiated by loss of plasma membrane, followed, after a short interval, by Z disc lysis and mitochondrial changes to constitute the picture of fully developed necrosis. Empty basal lamina tubes containing collagen indicated that regeneration may fail to occur. The tubes form a basis for collagen deposition. Evidence suggests that small patches of membrane loss can be repaired, though a slice of superficial cytoplasm is lost, and a piece of detached basal lamina results. The markedly hypercontracted fibres seen did not show features of necrosis.
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Cited by
The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle
Zubrzycka-Gaarn, E. E., Bulman, D. E., Karpati, G., Burghes, A. H. M., Belfall, B., Klamut, H. J., Talbot, J., Hodges, R. S., Ray, P. N., & Worton, R. G. (1988) · Nature · doi:10.1038/333466a0 · Cited by 658
Self-citationArahata, K., Ishiura, S., Ishiguro, T., Tsukahara, T., Suhara, Y., Eguchi, C., Ishiharat, T., Nonaka, I., Ozawa, E., & Sugita, H. (1988) · Nature · doi:10.1038/333861a0 · Cited by 566
Animal models for muscular dystrophy show different patterns of sarcolemmal disruption
Straub, V., Rafael, J. A., Chamberlain, J. S., & Campbell, K. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.2.375 · Cited by 488
Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein
Ho, M. (1994) · Cell · doi:10.1016/0092-8674(94)90136-8 · Cited by 260
Metadata
- Authors
- CARPENTER, S., & KARPATI, G.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1979
- Volume
- 102
- Issue
- 1
- Pages
- 147-161
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2083018473
- Cited by
- 202
- References
- 0
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DUCHENNE MUSCULAR DYSTROPHY: PLASMA MEMBRANE LOSS INITIATES MUSCLE CELL NECROSIS UNLESS IT IS REPAIRED. https://app.cochat.ai/papers/10.1093/brain/102.1.147
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- CARPENTER, S., & KARPATI, G. (1979). DUCHENNE MUSCULAR DYSTROPHY: PLASMA MEMBRANE LOSS INITIATES MUSCLE CELL NECROSIS UNLESS IT IS REPAIRED. Brain. https://doi.org/10.1093/brain/102.1.147
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
