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RETINAL VENOUS SHEATHING IN OPTIC NEURITIS: ITS SIGNIFICANCE FOR THE PATHOGENESIS OF MULTIPLE SCLEROSIS
Abstract
A systematic study of the frequency of retinal vascular abnormalities and cells in the media has been made in 50 patients presenting with acute optic neuritis. Abnormalities were found in 14 (fluorescein leakage in 10, perivenous sheathing in 6, cells in the vitreous in 6 and in the anterior chamber in 4; in 2 the cells in the media were seen without vascular changes). After a mean follow up of 3.5 years multiple sclerosis (MS) had developed in 8/14 patients with vascular abnormalities and/or evidence of inflammation and in 5/32 without; the difference is significant (P less than 0.02). The occurrence of perivenular abnormalities in a region free of myelin and oligodendrocytes provides evidence that the vascular changes in MS can occur independently of contiguous demyelination, and may be the primary event in the formation of a new lesion.
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Cited by
KERMODE, A. G., THOMPSON, A. J., TOFTS, P., MACMANUS, D. G., KENDALL, B. E., KINGSLEY, D. P. E., MOSELEY, I. F., RUDGE, P., & MCDONALD, W. I. (1990) · Brain · doi:10.1093/brain/113.5.1477 · Cited by 578
Self-citationPattern Electroretinography (PERG) and an Integrated Approach to Visual Pathway Diagnosis
Holder, G. E. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00030-6 · Cited by 368
Morphological and functional retinal impairment in Alzheimer's disease patients
Parisi, V., Restuccia, R., Fattapposta, F., Mina, C., Bucci, M. G., & Pierelli, F. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00620-4 · Cited by 344
Understanding uveitis: The impact of research on visual outcomes
de Smet, M. D., Taylor, S. R. J., Bodaghi, B., Miserocchi, E., Murray, P. I., Pleyer, U., Zierhut, M., Barisani-Asenbauer, T., LeHoang, P., & Lightman, S. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.06.005 · Cited by 340
Self-citationMicrocystic macular oedema in multiple sclerosis is associated with disease severity
Gelfand, J. M., Nolan, R., Schwartz, D. M., Graves, J., & Green, A. J. (2012) · Brain · doi:10.1093/brain/aws098 · Cited by 331
Metadata
- Authors
- LIGHTMAN, S., McDONALD, W. I., BIRD, A. C., FRANCIS, D. A., HOSKINS, A., BATCHOLER, J. R., & HALLIDAY, A. M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 110
- Issue
- 2
- Pages
- 405-414
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2180705783
- Cited by
- 165
- References
- 0
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: RETINAL VENOUS SHEATHING IN OPTIC NEURITIS: ITS SIGNIFICANCE FOR THE PATHOGENESIS OF MULTIPLE SCLEROSIS. https://app.cochat.ai/papers/10.1093/brain/110.2.405
- The paper
- LIGHTMAN, S., McDONALD, W. I., BIRD, A. C., FRANCIS, D. A., HOSKINS, A., BATCHOLER, J. R., & HALLIDAY, A. M. (1987). RETINAL VENOUS SHEATHING IN OPTIC NEURITIS: ITS SIGNIFICANCE FOR THE PATHOGENESIS OF MULTIPLE SCLEROSIS. Brain. https://doi.org/10.1093/brain/110.2.405
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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