Cited by 1,043Neurological diseases and metabolismParkinson's Disease Mechanisms and TreatmentsTrace Elements in Health

The DOI matches its Crossref record.

ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA

DEXTER, D. T., CARAYON, A., JAVOY-AGID, F., AGID, Y., WELLS, F. R., DANIEL, S. E, LEES, A. J., JENNER, P., MARSDEN, C. D.·1991·Brain

DOI 10.1093/brain/114.4.1953

Open this paper in CoChat — free account

Abstract

Levels of iron, copper, zinc and manganese were measured by inductively coupled plasma spectroscopy in frozen postmortem brain tissue from patients with Parkinson's disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy with strionigral degeneration (MSA), and Huntington's disease (HD) compared with control subjects. Total iron levels were found to be elevated in the areas of basal ganglia showing pathological change in these disorders. In particular, total iron content was increased in substantia nigra in PD, PSP and MSA, but not in HD. Total iron levels in the striatum (putamen and/or caudate nucleus) were increased in PSP, MSA and HD but not in PD. Total iron levels were decreased in the globus pallidus in PD. There were no consistent alterations of manganese levels in basal ganglia structures in any of the diseases studied. Copper levels were decreased in the substantia nigra in PD, and in the cerebellum in PSP, and were elevated in the putamen and possibly substantia nigra in HD. Zinc levels were only increased in PD, in substantia nigra and in caudate nucleus and lateral putamen. Levels of the iron binding protein ferritin were measured in the same patient groups using a radio-immunoassay technique. Increased iron levels in basal ganglia were generally associated with normal or elevated levels of ferritin immunoreactivity, for example, the substantia nigra in PSP and possibly MSA, and in putamen in MSA. The exception was PD where there was a generalized reduction in brain ferritin immunoreactivity, even in the substantia nigra. An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders. However, only in PD was there an increased total iron level, decreased ferritin content, decreased copper content, and an increased zinc concentration in substantia nigra. These findings suggest an alteration of iron handling in the substantia nigra in PD. Depending on the form in which the excess iron load exists in nigra in PD, it may contribute to the neurodegenerative process.

Integrity signals

Registry

Crossref · 10.1093/brain/114.4.1953

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 701–800 of 1,000

Translational Research in Neurology and Neuroscience 2010
Stüve, O., Kieseier, B. C., Hemmer, B., Hartung, H. P., Awad, A. M., Frohman, E. M., Greenberg, B. M., Racke, M. K., Zamvil, S. S., Phillips, J. T., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.158 · Cited by 15
Sub-Chronic Copper Pretreatment Reduces Oxidative Damage in an Experimental Huntington’s Disease Model
Martínez‐Lazcano, J. C., Montes, S., Sánchez-Mendoza, A., Rodríguez‐Páez, L., Pérez‐Neri, I., Boll, M., Campos-Arroyo, H. D., Rı́os, C., & Pérez‐Severiano, F. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0127-0 · Cited by 15
Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease
Casella, C., Kleban, E., Rosser, A., Coulthard, E. J., Rickards, H. E., Fasano, F., Metzler‐Baddeley, C., & Jones, D. K. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102658 · Cited by 15
Silica-embedded CdTe quantum dots functionalized with rhodamine derivative for instant visual detection of ferric ions in aqueous media
Kuang, Y., Wang, X., Tian, X., Yang, C., Li, Y., & Nie, Y. (2018) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2018.12.015 · Cited by 15
Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
Noh, J., & Chung, J.-M. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.5.578 · Cited by 15
MR Imaging of Midbrain Pathologies
Hattingen, E., Blasel, S., Nichtweiß, M., Zanella, F., & Weidauer, S. (2010) · Clinical Neuroradiology · doi:10.1007/s00062-010-0009-6 · Cited by 15
Transcranial brain sonography findings in Parkinson’s disease: implications for pathogenesis, early diagnosis and therapy
Walter, U. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.41 · Cited by 15
Emerging Applications for Quantitative Susceptibility Mapping in the Detection of Traumatic Brain Injury Pathology
Gozt, A., Hellewell, S. C., Ward, P. G. D., Bynevelt, M., & Fitzgerald, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.05.030 · Cited by 16
Pyruvate Prevents Dopaminergic Neurodegeneration and Motor Deficits in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson’s Disease
Kim, Y., Choi, S. Y., Hwang, O., & Lee, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03017-9 · Cited by 14
Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder
Alushaj, E., Hemachandra, D., Kuurstra, A. B., Menon, R. S., Ganjavi, H., Sharma, M., Kashgari, A., Barr, J., Reisman, W. M., KHAN, A. R., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103519 · Cited by 15
Inhibition of fibril formation by polyphenols: molecular mechanisms, challenges, and prospective solutions
Sharma, S., & Deep, S. (2024) · Chemical Communications · doi:10.1039/d4cc00822g · Cited by 15
The Function of the Metals in Regulating Epigenetics During Parkinson’s Disease
Wei, X., Cai, M., & Jin, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.616083 · Cited by 14
The Cyclic Nitroxide TEMPOL Ameliorates Oxidative Stress but Not Inflammation in a Cell Model of Parkinson’s Disease
Leathem, A., Simone, M., Dennis, J. M., & Witting, P. K. (2022) · Antioxidants · doi:10.3390/antiox11020257 · Cited by 17
Pharmacological manipulation of ataxia-telangiectasia kinase activity as a treatment for Parkinson’s disease
Shackelford, R. E., Manuszak, R. P., Heard, S. C., Link, C. J., & Wang, S. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.029 · Cited by 14
An Updated Overview of the Magnetic Resonance Imaging of Brain Iron in Movement Disorders
Tambasco, N., Nigro, P., Chiappiniello, A., Paoletti, F. P., Scialpi, S., Simoni, S., Chiarini, P., & Parnetti, L. (2022) · Behavioural Neurology · doi:10.1155/2022/3972173 · Cited by 14
Nitrosative/oxidative modifications and ageing
Musci, G., Persichini, T., Casadei, M., Mazzone, V., Venturini, G., Polticelli, F., & Colasanti, M. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.012 · Cited by 14
Texture analysis of ultrahigh field T2*‐weighted MR images of the brain: Application to Huntington's disease
Doan, N. T., van den Bogaard, S. J. A., Dumas, E. M., WEBB, A. G., van Buchem, M. A., Roos, R. A. C., van der Grond, J., Reiber, J. H. C., & Milles, J. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24199 · Cited by 12
An Integrated Strategy for Evaluation of Metabolic and Oxidative Defects in Neurodegenerative Illness Using Magnetic Resonance Techniques
Jenkins, B. G., Chen, Y. I., Küestermann, E. H. G. K., Makris, N., Nguyen, T., Kraft, E., Brownell, A., Rosas, H. D., Kennedy, D. N., Rosen, B. R., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07828.x · Cited by 14
Study protocol of IMAGINE-HD: Imaging iron accumulation and neuroinflammation with 7T-MRI + CSF in Huntington’s disease
van de Zande, N. A., Bulk, M., Najac, C., van der Weerd, L., de Bresser, J., Lewerenz, J., Ronen, I., & de Bot, S. T. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103450 · Cited by 16
The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease
Yao, L., Yang, Y., Yang, X., & Rezaei, M. J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04151-2 · Cited by 15
Quantitative susceptibility mapping of multiple system atrophy and Parkinson's disease correlates with neurotransmitter reference maps
Yan, S., Lu, J., Duan, B., Zhu, H., Liu, D., Li, L., Qin, Y., Li, Y., & Zhu, W. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106549 · Cited by 13
Dependence of brain‐tissue R 2 on MRI field strength
van Gelderen, P., Wang, Y., de Zwart, J. A., & Duyn, J. H. (2024) · Magnetic Resonance in Medicine · doi:10.1002/mrm.30400 · Cited by 13
Targeting Mitochondrial Metal Dyshomeostasis for the Treatment of Neurodegeneration
Liddell, J. R. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.15.19 · Cited by 13
Effective R2 relaxation rate, derived from dual-contrast fast-spin-echo MRI, enables detection of hemisphere differences in iron level and dopamine function in Parkinson’s disease and healthy individuals
Luo, J., & Collingwood, J. F. (2022) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2022.109708 · Cited by 13
A population‐specific symmetric phase model to automatically analyze susceptibility‐weighted imaging (SWI) phase shifts and phase symmetry in the human brain
Grabner, G., Haubenberger, D., Rath, J., et al. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22013 · Cited by 13
Carbonic Anhydrase I, II, and VI, Blood Plasma, Erythrocyte and Saliva Zinc and Copper Increase After Repetitive Transcranial Magnetic Stimulation
Henkin, R. I., Velicu, I., Potolicchio, S. J., Levy, L. M., Martin, B. M., & Moharram, R. (2010) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181cda0e3 · Cited by 13
Existing dopaminergic therapies for Parkinson’s disease
Dutta, A. K., & Le, W. (2006) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.16.12.1613 · Cited by 13
Can transverse relaxation rates in deep gray matter be approximated from functional and T2-weighted FLAIR scans for relative brain iron quantification?
Garzón, B., Sitnikov, R., Bäckman, L., & Kalpouzos, G. (2017) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2017.04.005 · Cited by 13
H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
Kim, Y., Stahl, M. C., Huang, X., & Connor, J. R. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15107 · Cited by 14
Reference values for trace element levels in the human brain: A systematic review of the literature
Ramos, P., Pinto, E., Santos, A., et al. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126745 · Cited by 13
Iron, Oxygen Radicals, and Disease
Nelson, S. K., & McCord, J. M. (1998) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60036-3 · Cited by 13
Neurobehavioural deficits following postnatal iron overload: II instrumental learning performance
Archer, T., Schoröder, N., & Fredriksson, A. (2003) · Neurotoxicity Research · doi:10.1007/bf03033374 · Cited by 13
Parkinson's disease
Marsden, C. D. (1992) · Postgraduate Medical Journal · doi:10.1136/pgmj.68.801.538 · Cited by 13
Self-citation
Reaction of dopamine with d-glyceraldehyde under biomimetic conditions: stereoselective formation of tetrahydroisoquinolines and rate-accelerating effects of transition metal ions
Manini, P., d’Ischia, M., Lanzetta, R., et al. (1999) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(99)00208-4 · Cited by 13
Cellular and regional maintenance of iron homeostasis in the brain: normal and diseased states
Connor, J. R. (1993) · Key topics in brain research · doi:10.1007/978-3-7091-9322-8_1 · Cited by 14
The oligoelements
Carvalho, D. C., Coelho, L. M., Acevedo, M. S. M. S. F., et al. (2015) · doi:10.1002/9781118654316.ch5 · Cited by 13
Alzheimer's and Parkinson's diseases: An environmental proteomic point of view
Demartini, D. R., Schilling, L. P., da Costa, J. C., & Carlini, C. R. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.04.014 · Cited by 14
Effectiveness of QSM Over R2* in Assessment of Parkinson's Disease - A Systematic Review
Pendem, S., & Priyanka (2020) · Neurology India · doi:10.4103/0028-3886.284377 · Cited by 14
A Standardized MR Imaging Protocol for Parkinsonism
Reimão, S., Guerreiro, C., Seppi, K., Ferreira, J. J., & Poewe, W. H. (2020) · Movement Disorders · doi:10.1002/mds.28204 · Cited by 12
Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation
Singh, G., Mittra, N., & Singh, C. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04620-z · Cited by 12
A Systematic DFT Study of Some Plausible Zn(II) and Al(III) Interaction Sites in N-Terminally Acetylated α-Synuclein
Ramis, R., Ortega‐Castro, J., Vilanova, B., Adrover, M., & Frau, J. (2017) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.7b10744 · Cited by 12
Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease
Milanese, C., Gabriels, S., Barnhoorn, S., Cerri, S., Ulusoy, A., Gornati, S. V., Wallace, D. F., Blandini, F., Monte, D. A. D., Subramaniam, V. N., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00698-4 · Cited by 13
Cerebrospinal fluid levels of oxidative stress measured using diacron-reactive oxygen metabolites and biological antioxidant potential in patients with Parkinson’s disease and progressive supranuclear palsy
Takahashi, K., Iwaoka, K., Takahashi, K., Suzuki, Y., Taguchi, K., Yamahara, K., & Maeda, T. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135975 · Cited by 12
Parkinson’s disease: diagnostic potential of high-resolution phase difference enhanced MR imaging at 3 T
Kakeda, S., Korogi, Y., Yoneda, T., et al. (2012) · European Radiology · doi:10.1007/s00330-012-2680-2 · Cited by 12
Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia SystemsPreprint
Lazaridis, I., Crittenden, J. R., Ahn, G., Hirokane, K., Yoshida, T., Wickersham, I. R., Mahar, A., Skara, V., Loftus, J. H., Parvataneni, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.01.596922 · Cited by 12
Nigral Iron Deposition Influences Disease Severity by Modulating the Effect of Parkinson’s Disease on Brain Networks
Wen, J., Guo, T., Wu, J., Bai, X., Zhou, C., Wu, H., Liu, X., Chen, J., Cao, Z., Gu, L., et al. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223372 · Cited by 10
The ‘α-synucleinopathy syndicate’: multiple system atrophy and Parkinson’s disease
Sian‐Hülsmann, J., & Riederer, P. F. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02653-2 · Cited by 13
Zeolite and Neurodegenerative Diseases
Panaiotov, S., Tancheva, L. P., Kalfin, R. E., & Petkova-Kirova, P. S. (2024) · Molecules · doi:10.3390/molecules29112614 · Cited by 15
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives
Olesen, M. A., Villavicencio-Tejo, F., Cuevas-Espinoza, V., & Quintanilla, R. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102594 · Cited by 12
Mathematical approach to understand the kinetics of α-synuclein aggregation: Relevance to Parkinson's disease
Bharathi, P., Nagabhushan, P. N., & Rao, K. S. J. (2008) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2008.08.008 · Cited by 12
Relationship Between Iron Distribution in Deep Gray Matter Nuclei Measured by Quantitative Susceptibility Mapping and Motor Outcome After Deep Brain Stimulation in Patients With Parkinson's Disease
Zhao, W., Yang, C., Tong, R. M., et al. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28574 · Cited by 11
The effects of the 21-aminosteroid U-74389G on spatial orientation in rats after a cerebral oligemic episode and iron-induced oxidative stress
Heim, C. C., Kolasiewicz, W., & Sontag, K. ‐. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050008 · Cited by 11
The possible mechanism of Parkinson’s disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine
Xu, R., Zhou, Y., Fang, X., Lü, Y., Li, J., Zhang, J., Deng, X., & Li, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.053 · Cited by 11
Assessing of plasma levels of iron, zinc and copper in Iranian Parkinson's disease
Meamar, R., Nikyar, H., Dehghani, L., et al. (2016) · Advanced Biomedical Research · doi:10.4103/2277-9175.178788 · Cited by 11
From niche methods to necessary tools: The growing importance of analytical atomic spectrometry in metal imaging in neuroscience
McAllum, E. J., & Hare, D. J. (2019) · Spectrochimica Acta Part B Atomic Spectroscopy · doi:10.1016/j.sab.2019.04.009 · Cited by 11
Nigral Iron Deposition Is Associated With Levodopa-Induced Dyskinesia in Parkinson’s Disease
Song, T., Li, J., Mei, S., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.647168 · Cited by 11
Calcium channels and iron metabolism: A redox catastrophe in Parkinson's disease and an innovative path to novel therapies?
Boag, M. K., Ma, L., Mellick, G. D., Pountney, D. L., Feng, Y., Quinn, R. J., Liew, A. W., Dharmasivam, M., Azad, M. G., Afroz, R., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102136 · Cited by 13
Adaptive cellular response of the substantia nigra dopaminergic neurons upon age‐dependent iron accumulation
Kwon, K., Cho, H., Lee, S.-Y., Cho, E. J., Yu, W., Kok, C. Y. L., Je, H. S., Kim, J., Cho, H. J., & Kwon, T. (2022) · Aging Cell · doi:10.1111/acel.13694 · Cited by 9
Neurochemistry of Parkinson's disease
Rao, J. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)83007-7 · Cited by 11
α-Synuclein Aggregation and Parkinson’s Disease
Uversky, V. N. (2007) · Springer eBooks · doi:10.1007/978-0-387-36534-3_4 · Cited by 11
Quantitative assessment of brain iron by R 2* relaxometry in patients with cervical dystonia
Aschermann, Z., Perlaki, G., Orsi, G., Nagy, S. A., Horváth, A., Bóné, B., Bihari, K., Ács, P., Janszky, J., Komoly, S., et al. (2015) · Movement Disorders · doi:10.1002/mds.26306 · Cited by 11
Validation of a brain MRI relaxometry protocol to measure effects of preterm birth at a flexible postnatal age
Maitre, N. L., Slaughter, J. C., Stark, A. R., Aschner, J. L., & Anderson, A. W. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-84 · Cited by 11
Lactoferrin is Synthesized by Mouse Brain Tissue and Its Expression is Enhanced after MPTP Treatment
Fillebeen, C., Dexter, D. T., Mitchell, V., et al. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-9068-9_36 · Cited by 11
Self-citation
Levels of α‐ and β‐synuclein regulate cellular susceptibility to toxicity from α‐synuclein oligomers
Angelova, D. M., Jones, H. B. L., & Brown, D. R. (2017) · The FASEB Journal · doi:10.1096/fj.201700675r · Cited by 12
Tau Positron Emission Tomography Imaging in Degenerative Parkinsonisms
Lyoo, C. H., Cho, H., Choi, J. Y., Ryu, Y. H., & Lee, M. S. (2018) · Journal of Movement Disorders · doi:10.14802/jmd.17071 · Cited by 12
Prevention and Therapy of Neurodegenerative Disorders: Role of Nutritional Antioxidants
Matteo, V. D., Pierucci, M., Giovanni, G. D., & Esposito, E. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50168-x · Cited by 11
Neurochemical Roles of Copper as Antioxidant or Prooxidant
Prohaska, J. R. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0197-2_4 · Cited by 11
Pictet–Spengler condensation of the antiparkinsonian drug l-DOPA with d-glyceraldehyde. Opposite kinetic effects of Fe3+ and Cu2+ ions and possible implications for the origin of therapeutic side effects
Manini, P., d’Ischia, M., & Prota, G. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(00)00309-6 · Cited by 11
Effect of asphyxia on the composition of cationic elements in the perilymph
Hara, A., Komeno, M., Senarita, M., Serizawa, F., Ishikawa, T., & Kusakari, J. (1995) · Hearing Research · doi:10.1016/0378-5955(95)00166-3 · Cited by 11
Mitochondrial Dysfunction Contributes To Zinc-induced Neurodegeneration: a Link with NADPH Oxidase
Chauhan, A. K. S., Mittra, N., Singh, G., & Singh, C. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02008-8 · Cited by 11
NOX2-TRPM2 coupling promotes Zn2+ inhibition of complex III to exacerbate ROS production in a cellular model of Parkinson’s disease
AlAhmad, M., Isbea, H., Shitaw, E., Li, F., & Sivaprasadarao, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-66630-9 · Cited by 11
α-Synuclein Iron-Responsive-Element RNA and Iron Regulatory Protein Affinity Is Specifically Reduced by Iron in Parkinson’s Disease
Khan, M. A. (2025) · Biomolecules · doi:10.3390/biom15020214 · Cited by 12
Transient sampling of aggregation‐prone conformations causes pathogenic instability of a parkinsonian mutant of DJ ‐1 at physiological temperature
Milkovic, N. M., Catazaro, J., Lin, J., et al. (2015) · Protein Science · doi:10.1002/pro.2762 · Cited by 10
Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding
Solari, V., Rudd, T. R., Guimond, S. E., et al. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00564g · Cited by 10
Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study
Peckham, M. E., Dashtipour, K., Holshouser, B. A., et al. (2016) · Radiology Research and Practice · doi:10.1155/2016/9305018 · Cited by 10
Subthalamic Nucleus Activation Occurs Early during Stopping and Is Associated with Trait Impulsivity
Yoon, J. H., Cui, E. D. B., Minzenberg, M., & Carter, C. S. (2019) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01370 · Cited by 13
Nigral diffusivity, but not free water, correlates with iron content in Parkinson’s disease
Langley, J. A., Huddleston, D. E., & Hu, X. P. (2021) · Brain Communications · doi:10.1093/braincomms/fcab251 · Cited by 9
Effects of intrahippocampal NAC61–95 injections on memory in the rat and attenuation with vitamin E
Kim, E.-M., Elliot, J. J., Hobson, P., & O‘Hare, E. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.020 · Cited by 10
Effects of exposure to static magnetic field on motor skills and iron levels in plasma and brain of rats
Elferchichi, M., Ammari, M., Maâroufi, K., Sakly, M., & Abdelmelek, H. (2011) · Brain Injury · doi:10.3109/02699052.2011.581640 · Cited by 10
ATP in cellular calcium-overload by trivalent metal ions
Anghileri, L. J., & Thouvénot, P. (1998) · Biological Trace Element Research · doi:10.1007/bf02820027 · Cited by 10
Molecular mechanism of monoamine toxicity in Parkinson’s disease: hypothetical cell death model
Jiménez-Del-Río, M., & Velez‐Pardo, C. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0839 · Cited by 10
Iron deposits in brain disorders
Jellinger, K. A., & Kienzl, E. (1993) · Key topics in brain research · doi:10.1007/978-3-7091-9322-8_2 · Cited by 11
In silico evidence for glutathione- and iron-related pathogeneses in Parkinson's disease
Yeager, M. P., & Coleman, R. A. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.01.034 · Cited by 9
Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders
Castiglioni, E., Finazzi, D., Goldwurm, S., Pezzoli, G., Forni, G., Girelli, D., Maccarinelli, F., Poli, M., Ferrari, M., Cremonesi, L., et al. (2010) · Parkinson's Disease · doi:10.4061/2011/827693 · Cited by 12
Selegiline increases heme oxygenase-1 expression and the cytotoxicity produced by dopamine treatment of neuroblastoma SK-N-SH cells
Rieder, C. R. D. M., Williams, A. C., & Ramsden, D. B. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000700015 · Cited by 9
Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington’s Disease
Fox, J. H., Lü, Z., & Barrows, L. F. (2016) · PLoS Currents · doi:10.1371/currents.hd.b966ec2eca8e2d89d2bb4d020be4351e · Cited by 9
Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism
Chauhan, A. K. S., Mittra, N., Singh, B. K., et al. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3415-8 · Cited by 9
Mössbauer Studies of Pathological Brain Tissues Affected by PSP Disease
Gałązka-Friedman, J., Bauminger, E. R., Szlachta, K. A., et al. (2009) · Acta Physica Polonica A · doi:10.12693/aphyspola.115.545 · Cited by 9
Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington’s Disease Mutation
Berggren, K. L., Agrawal, S., Fox, J. A., Hildenbrand, J. R. V., Nelson, R., Bush, A. I., & Fox, J. H. (2017) · Journal of Huntington s Disease · doi:10.3233/jhd-170242 · Cited by 9
BFRnet: A deep learning-based MR background field removal method for QSM of the brain containing significant pathological susceptibility sources
Zhu, X., Gao, Y., Liu, F., et al. (2022) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2022.08.001 · Cited by 9
Reanalysis of DIA Data Demonstrates the Capabilities of MS/MS-Free Proteomics to Reveal New Biological Insights in Disease-Related Samples
Ivanov, M. V., Kopeykina, A. S., & Gorshkov, M. V. (2024) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.4c00134 · Cited by 8
Reviewing Biochemical Implications of Normal and Mutated Huntingtin in Huntington’s Disease
Tellone, E., Galtieri, A., & Ficarra, S. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190621101909 · Cited by 9
The application of bathophenanthroline for the determination of free iron in parallel with hROS in microdialysis samples
Freinbichler, W., Misini, B., Colivicchi, M. A., Linert, W., Tipton, K. F., & Corte, L. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108530 · Cited by 9
Susceptibility‐Weighted 3T MRI of the Swallow Tail Sign in Multiple Sclerosis: A Case Control Study
Weber, C. E., Ebert, A., Platten, M., Gass, A., & Eisele, P. (2020) · Journal of Neuroimaging · doi:10.1111/jon.12775 · Cited by 8
Quantitative susceptibility mapping from basal ganglia and related structures: correlation with disease severity in progressive supranuclear palsy
Krishnan, S., George, S. S., Radhakrishnan, V., Raghavan, S., Thomas, B., Thulaseedharan, J. V., & Puthenveedu, D. K. (2023) · Acta Neurologica Belgica · doi:10.1007/s13760-023-02352-5 · Cited by 8
Parkinson’s Disease
Sikiö, M., Holli, K. K., Harrison, L., et al. (2011) · Academic Radiology · doi:10.1016/j.acra.2011.06.007 · Cited by 8
Effects of carboxylic acids on the uptake of non-transferrin-bound iron by astrocytes
Keenan, B. M., Robinson, S. R., & Bishop, G. M. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.009 · Cited by 8
Substantia nigra hyperechogenicity in hypokinetic Huntington’s disease patients
Lambeck, J., Niesen, W., Matthias, R., et al. (2015) · Journal of Neurology · doi:10.1007/s00415-014-7587-1 · Cited by 8
Brain lipid composition in postnatal iron‐induced motor behavior alterations following chronic neuroleptic administration in mice
Isaac, G., Fredriksson, A., Danielsson, R., Eriksson, P., & Bergquist, J. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05236.x · Cited by 8
Heme-coordinated histidine residues form non-specific functional ferritin-heme peroxidase system: Possible and partial mechanistic relevance to oxidative stress-mediated pathology in neurodegenerative diseases
Esmaeili, S., Ashrafi-Kooshk, M. R., Asghari, S. M., & Khodarahmi‬, R. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.05.059 · Cited by 8

Authors: DEXTER, D. T., CARAYON, A., JAVOY-AGID, F., AGID, Y., WELLS, F. R., DANIEL, S. E., LEES, A. J., JENNER, P., & MARSDEN, C. D.
Affiliations: King's College London (GB)
Inserm (FR)
Parkinson's UK (GB)
Corresponding author: JENNER, P.
ORCID: DEXTER, D. T.
DANIEL, S. E
LEES, A. J.
JENNER, P.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 1991
Volume: 114
Issue: 4
Pages: 1953-1975
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/114.4.1953
OpenAlex: W2123913108
Cited by: 1,043
References: 0
Citations by year: 2026: 18 · 2025: 29 · 2024: 47 · 2023: 28 · 2022: 37 · 2021: 43 · 2020: 36 · 2019: 38 · 2018: 30 · 2017: 45 · 2016: 56 · 2015: 45 · 2014: 41 · 2013: 44 · 2012: 32
FWCI: 12.57
Type: journal article
Language: en
Open access: closed
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Royal Society
Topics: Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: Parkinson's disease, progressive supranuclear palsy, multiple system atrophy, Huntington's disease, basal ganglia, iron, ferritin, copper, zinc, manganese, substantia nigra, striatum, globus pallidus, neurodegeneration, trace metals, iron overload
MeSH terms: Aging, Atrophy, Basal Ganglia Diseases, Brain, Brain Diseases, Ferritins, Humans, Huntington Disease, Iron, Metals, Parkinson Disease, Radioimmunoassay, Reference Values, Supranuclear Palsy, Progressive, Trace Elements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks