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Primary progressive multiple sclerosis
Open accessAbstract
Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration. The prognosis is poor and there are currently no treatment trials for this form of the disease.
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Citations
Cited by
Cortical demyelination and diffuse white matter injury in multiple sclerosis
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836
The Immunopathology of Multiple Sclerosis: An Overview
Lassmann, H., Brück, W., & Lucchinetti, C. F. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00064.x · Cited by 1,182
The natural history of multiple sclerosis:a geographically based study
Cottrell, D. A., Kremenchutzky, M., Rice, G. P. A., Koopman, W. J., Hader, W., Baskerville, J., & Ebers, G. C. (1999) · Brain · doi:10.1093/brain/122.4.625 · Cited by 1,163
Evidence of early cortical atrophy in MS: Relevance to white matter changes and disability
De Stefano, N., Matthews, P. M., Filippi, M., Agosta, F., De Luca, M., Bartolozzi, M. L., Guidi, L., Ghezzi, A., Montanari, E., Cifelli, A., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000055926.69643.03 · Cited by 489
Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.
Choi, S. R., Howell, O. W., Carassiti, D., Magliozzi, R., Gveric, D., Muraro, P. A., Nicholas, R., Roncaroli, F., & Reynolds, R. (2012) · Brain · doi:10.1093/brain/aws189 · Cited by 386
Metadata
- Authors
- Thompson, A.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-06-01
- Volume
- 120
- Issue
- 6
- Pages
- 1085-1096
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2189829250
- Cited by
- 506
- References
- 0
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Thompson, A. (1997). Primary progressive multiple sclerosis. Brain. https://doi.org/10.1093/brain/120.6.1085
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
