The DOI matches its Crossref record; 436 of the 436 references it cites were found in a registry or an index.
The amyloid cascade hypothesis: an updated critical review
Open accessAbstract
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer’s disease have created excitement and have been heralded as corroboration of the amyloid cascade hypothesis. However, while Aβ may contribute to disease, genetic, clinical, imaging and biochemical data suggest a more complex aetiology. Here we review the history and weaknesses of the amyloid cascade hypothesis in view of the new evidence obtained from clinical trials of anti-amyloid antibodies. These trials indicate that the treatments have either no or uncertain clinical effect on cognition. Despite the importance of amyloid in the definition of Alzheimer’s disease, we argue that the data point to Aβ playing a minor aetiological role. We also discuss data suggesting that the concerted activity of many pathogenic factors contribute to Alzheimer’s disease and propose that evolving multi-factor disease models will better underpin the search for more effective strategies to treat the disease.
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2 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
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RetractedRETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
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Alzheimer's disease: the amyloid cascade hypothesis
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The amyloid hypothesis of Alzheimer's disease at 25 years
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Cited by
Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138
“78,111,112 115 However, FAD mutations are not necessarily linked to an increase in A β 42 levels or an elevation of A β 42 /A β 40 ratio.”
BackgroundAnti-Amyloid Therapies for Alzheimer’s Disease and the Amyloid Cascade Hypothesis
Fedele, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914499 · Cited by 102
Kamila, P., Kar, K., Chowdhury, S., Chakraborty, P., Dutta, R., S, S., Singh S, A., & Prajapati, B. G. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.05.005 · Cited by 90
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Self-citationOnce upon a time, the Amyloid Cascade Hypothesis
Granzotto, A., & Sensi, S. L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102161 · Cited by 57
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Metadata
- Authors
- Kepp, K. P., Robakis, N. K., Høilund-Carlsen, P. F., Sensi, S. L., & Vissel, B.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2023-05-15
- Volume
- 146
- Issue
- 10
- Pages
- 3969-3990
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W4376614794
- Cited by
- 284
- References
- 436
- FWCI
- 41.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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