Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
Irwin, David J., Cohen, Todd J., Grossman, Murray, Arnold, Steven E., Xie, Sharon X., Lee, Virginia M.-Y., Trojanowski, John Q.·2012·Brain
Cited by (282)
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- An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degenerationMadison I. J. Honey, Yanaika S. Hok‐A‐Hin, Elisabeth H. Thijssen, Katheryn A Q Cousins, Babette van der Weijden, Lisanne in ‘t Veld, Erik Stoops, Sterre C.M. de Boer, Flora Hillegonde Duits, Julie F. H. De Houwer et al. · 2026 · Nature Medicine
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- Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological contextCristina Di Primio, Valentina Quercioli, Giacomo Siano, Branislav Kováčech, M Novák, Antonino Cattaneo · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
- SUMO inhibits Tau aggregation in Alzheimer’s diseaseSubashchandrabose Chinnathambi, Nagaraj Rangappa · 2025 · Advances in protein chemistry and structural biology
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- Post-translational modifications as a regulatory code for tau function in health and diseaseAbigail J. Nordbeck, Bhirisha Sharma, Charles A. Garcia, Jui‐Heng Tseng · 2026 · Frontiers in Dementia
- Acetylation encodes Tau aggregationYouqi Tao, Dan Li · 2023 · Structure
- Molecular Pathways in Alzheimer’s Disease and Cognitive FunctionXu Chen, Meredith C. Reichert, Li Gan · 2016 · Elsevier eBooks
- The α-Tubulin Deacetylase HDAC6 in Aggresome Formation and AutophagyChristiane Richter‐Landsberg · 2015 · Elsevier eBooks
- Insights to develop tau‐directed therapeutics to protect the synaptic integrity for tauopathiesEunji Cha, Hak Joong Kim, Sang Min Lim · 2023 · Bulletin of the Korean Chemical Society
- Protective association of HLA-DRB1*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequencesEmmanuel Jean-Marie Mignot, Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris E. Jansen, Eric Yu, Aude Nicolas, Itziar de Rojas, Thiago Peixoto Leal et al. · 2022 · Research Square
- Chidamide enhances the sensitivity of gastric cancer to 5-fluorouracil chemotherapy by suppressing the HDAC3/HNF4A/TYMS axisXiaofei Zhang, Lei Shi, Yaping Gao, Chenyi Zhou, Xiyin Wang, Xiaonan Shi · 2025 · Cell Death and Disease
- Alzheimer’s diseaseCharles J. Duyckaerts · 2014 · Cambridge University Press eBooks
- Protein Lysine Acetylated/Deacetylated Enzymes and the Metabolism-Related DiseasesQilin Wang, Shangjing Guo, Yaman Gao · 2016 · Advances in Bioscience and Biotechnology
- Protein Misfolding, Neurodegeneration and TauPierfausto Seneci · 2015 · Elsevier eBooks
- Frontotemporal lobar degenerationBoram Kim, Ashley Viera-Ortiz, Jessica M. Phan, David John Irwin, Edward B. Lee · 2022 · Elsevier eBooks
- Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapyBruno Vasconcelos, Matthew Bird, Ilie‐Cosmin Stancu, Dick Terwel, Ilse Dewachter · 2017 · Elsevier eBooks
- Tau Protein: Targets And Development Against Alzheimer’s DiseaseSonal Dubey, Mahesh AR · 2023 · BENTHAM SCIENCE PUBLISHERS eBooks
- Impact of Lysine Acetylation Mutations on the Structure of Full-Length Tau FibrilsAurelio James Dregni, Mei Hong · 2025 · ACS Chemical Neuroscience
- On the potential roles of TDP-43 in the formation of membraneless organelles and their transformation into toxic aggregatesOlga S. Sergeeva, Margarita V. Neklesova, Vladislav A. Reushev, Alexey V. Artemov, Туроверов Константин Константинович, Туроверов Константин Константинович, Vladimir Nikolaevich Uversky, Alexander V. Fonin · 2025 · Biochemical and Biophysical Research Communications
- Effect of site-specific lysine acetylation on tau binding to microtubules: mechanistic insights from all-atom molecular dynamics simulationsPengxuan Xia, Dushuo Feng, Bote Qi, Lulu Guan, Yunxiang Sun, Yu Zou · 2026 · Physical Chemistry Chemical Physics
- Pathogenesis of neurodegenerative diseases via templated recruitmentJing Guo · 2013 · ScholarlyCommons (University of Pennsylvania)
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- Pathophysiology and Management Approaches in Alzheimer’s DiseaseShreshta Jain, Divya Goel, Sheikh Sana Nazir, Vaishali Yadav, Divya Vohora · 2023 · Springer eBooks
- Fluid and Imaging Markers of Frontotemporal Lobar DegenerationFieke Prinse, Julie F. H. De Houwer, Elise G.P. Dopper, Harro Seelaar · 2025 · Springer eBooks
- Immunotherapy Against Acetylated Tau at K280 Ameliorates Behavioral Impairments and Pathologies of Tau Transgenic MouseNa-Young Kim, Ha‐Lim Song, Kwangmin Cho, Young-Lim Shim, Kyounghye Lee, Yeon‐Seon Mun, Seung‐Eun Lee, Min-Seok Kim, Hyun-Ju Kim, Dong‐Hou Kim et al. · 2020
- NEURODEGENERATIVE DISEASES AND TAU: PATHOLOGICAL EVENTS AND MOLECULAR TARGETSPierfausto Seneci · 2012 · Istituto Lombardo - Accademia di Scienze e Lettere - Rendiconti di Scienze
- DEVELOPMENT OF A LIVE-CELL ASSAY PLATFORM TO STUDY PROTEIN-PROTEIN INTERACTIONS OF MICROTUBULE-ASSOCIATED PROTEIN TAUNiko-Petteri Nykänen · 2012 · UEF eRepo (University of Eastern Finland)
- The regulation of phosphorylation of tau protein in Alzheimer's diseaseDi Tang, Han‐Chang Huang, Zhao-Feng Jiang · 2013 · Shengming de Huaxue
- Protein Aggregation and Neurodegeneration: Tauopathies and SynucleinopathiesMichel Goedert · 2017 · Neurodegeneration
- SHORT COMMUNICATION Acetylated Tau Neuropathology in Sporadic and Hereditary TauopathiesDavid John Irwin, Todd J. Cohen, Murray Grossman, Steven Edward Arnold, Vivianna M. Van Deerlin, Y. Lee, John Q. Trojanowski · 2013
- The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structureBrian H. Constance · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
- Posttranslational modifications of TDP-43Samir Rahman · 2021 · Elsevier eBooks
- Cellular Mechanisms of DementiaLi Gan · 2017 · Oxford University Press eBooks
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- Additional file 5 of Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSanjib K Guha, Fischer, Sarah, Johnson, Gail V. W., Nehrke, Keith · 2020 · Figshare
- Additional file 6 of Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSanjib K Guha, Fischer, Sarah, Johnson, Gail V. W., Keith W. Nehrke · 2020 · Figshare
- Additional file 3 of Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSanjib K Guha, Fischer, Sarah, Johnson, Gail V. W., Nehrke, Keith · 2020 · Figshare
- Additional file 2 of Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSanjib K Guha, Fischer, Sarah, Johnson, Gail V. W., Nehrke, Keith · 2020 · Figshare
- Additional file 4 of Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSanjib K Guha, Fischer, Sarah, Johnson, Gail V. W., Nehrke, Keith · 2020 · Figshare
- Additional file 1 of Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic modelSanjib K Guha, Fischer, Sarah, Johnson, Gail V. W., Keith W. Nehrke · 2020 · Figshare
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- Ultrastructural remodelling of tau fibrils during ghost tangle formation in Alzheimer’s disease brainDaniel A. Stähli, Louis Travers, Notash Shafiei, Lukas van den Heuvel, Eglantine Vialaneix, Philippine L Schneider, Annemieke J.M. Rozemüller, Wilma D. J. van de Berg, Henning Stahlberg, Amanda J. Lewis · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
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- Next-generation brain proteomics: Integrating single-cell, spatial, and multi-omics for clinical biomarker discoveryArup Acharjee, Nitika Rai, Akash Patel, Papia Acharjee · 2026 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Alcohol-induced dysregulation of tau and acetylation pathways in the pathogenesis of Alzheimer’s diseaseKC Basavaraju, Harshitha D K, Poornima Priyadarshini C. G. · 2026 · Neuroscience
- Multivalent ubiquitin recognition regulates multiple stages of Tau self-assemblyKevin Muwonge, Luis Fernando Durán-Armenta, Tamás Lázár, Attila Mészáros, Alexander N. Volkov, Alvaro M. Navarro, Cristina Marino‐Buslje, María Laura Fernández, Gustavo J. Gutierrez, Nicholas M. Kanaan et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Safe and efficient intracellular delivery of functional antibodies into cultured neural cells shows a role for Alzheimer’s-relevant tau phosphorylation in cell integrityKirsten L. Viola, Brett A. Chromy, Raghad Nowar, Mary P. Lambert, Klein William L. · 2026 · Frontiers in Dementia