Cited by 321Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsCerebrospinal fluid and hydrocephalus

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IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

Kunis, Gilad, Baruch, Kuti, Rosenzweig, Neta, Kertser, Alexander, Miller, Omer, Berkutzki, Tamara, Schwartz, Michal·2013·Brain

DOI 10.1093/brain/awt259

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Abstract

Infiltrating T cells and monocyte-derived macrophages support central nervous system repair. Although infiltration of leucocytes to the injured central nervous system has recently been shown to be orchestrated by the brain's choroid plexus, the immunological mechanism that maintains this barrier and regulates its activity as a selective gate is poorly understood. Here, we hypothesized that CD4(+) effector memory T cells, recently shown to reside at the choroid plexus stroma, regulate leucocyte trafficking through this portal through their interactions with the choroid plexus epithelium. We found that the naïve choroid plexus is populated by T helper 1, T helper 2 and regulatory T cells, but not by encephalitogenic T cells. In vitro findings revealed that the expression of immune cell trafficking determinants by the choroid plexus epithelium is specifically induced by interferon-γ. Tumour necrosis factor-α and interferon-γ reciprocally controlled the expression of their receptors by the choroid plexus epithelium, and had a synergistic effect in inducing the epithelial expression of trafficking molecules. In vivo, interferon-γ-dependent signalling controlled trafficking through the choroid plexus; interferon-γ receptor knockout mice exhibited reduced levels of T cells and monocyte entry to the cerebrospinal fluid and impaired recovery following spinal cord injury. Moreover, reduced expression of trafficking molecules by the choroid plexus was correlated with reduced CD4(+) T cells in the choroid plexus and cerebrospinal fluid of interferon-γ receptor knockout mice. Similar effect on the expression of trafficking molecules by the choroid plexus was found in bone-marrow chimeric mice lacking interferon-γ receptor in the central nervous system, or reciprocally, lacking interferon-γ in the circulation. Collectively, our findings attribute a novel immunological plasticity to the choroid plexus epithelium, allowing it to serve, through interferon-γ signalling, as a tightly regulated entry gate into the central nervous system for circulating leucocytes immune surveillance under physiological conditions, and for repair following acute injury.

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Stock, A. D., Ben‐Zvi, A., & Putterman, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47927-1.00023-2 · Cited by 1
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Rapôso, C., & Schwartz, M. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch11
Self-citation
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Self-citation
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Barrera, R. H. R. (2017) · doi:10.24275/uami.3t945q76s
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White, M. P. J. (2015) · doi:10.26686/wgtn.17012330.v1
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Catalão, C. H. R., Petronilho, F. C., Dal‐Pizzol, F., Pillai, A., Giridharan, V. V., & Barichello, T. (2024) · Research Square · doi:10.21203/rs.3.rs-3829658/v1
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Moore, E., Ben‐Zvi, A., & Putterman, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93232-5.00032-0
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Drevets, D. A., Laman, J. D., & Leenen, P. J. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00073-9
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Schmidt, S., & Rudolph, H. (2025) · Current human cell research and applications · doi:10.1007/978-981-97-9495-9_9
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Wildemann, B., & Haas, J. (2025) · Current human cell research and applications · doi:10.1007/978-981-97-9495-9_8
Additional file 1 of Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Zheng, W., Feng, Y., Zeng, Z., Ye, M., Wang, M., Liu, X., Tang, P., Shang, H., Sun, X., Lin, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19200021
Additional file 2 of Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Zheng, W., Feng, Y., Zeng, Z., Ye, M., Wang, M., Liu, X., Tang, P., Shang, H., Sun, X., Lin, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19200024
Additional file 2 of Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke
Wang, J., Liu, R., Hasan, M. N., Fischer, S., Chen, Y., Como, M., Fiesler, V. M., Bhuiyan, M. I. H., Dong, S., Li, E., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19589429

Authors: Kunis, G., Baruch, K., Rosenzweig, N., Kertser, A., Miller, O., Berkutzki, T., & Schwartz, M.
Affiliations: Weizmann Institute of Science (IL)
ORCID: Baruch, Kuti
Rosenzweig, Neta
Kertser, Alexander
Schwartz, Michal
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2013-10-01
Volume: 136
Issue: 11
Pages: 3427-3440
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awt259
OpenAlex: W2112350141
Cited by: 321
References: 57
Citations by year: 2026: 14 · 2025: 28 · 2024: 27 · 2023: 31 · 2022: 34 · 2021: 26 · 2020: 28 · 2019: 23 · 2018: 18 · 2017: 25 · 2016: 22 · 2015: 25 · 2014: 17 · 2013: 3
FWCI: 12.53
Type: journal article
Language: en
Open access: closed
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Keywords: choroid plexus, interferon-gamma, choroid plexus epithelium, Th1 cells, regulatory T cells, Th2 cells, interferon-gamma receptor, TNF-α, cerebrospinal fluid, spinal cord injury, CNS repair, immune surveillance, monocyte-derived macrophages, CD4+ T cells, bone marrow chimeric mice
MeSH terms: Interferon gamma Receptor, Animals, Cell Movement, Central Nervous System, Choroid Plexus, Epithelium, Female, Interferon-gamma, Male, Mice, Inbred C57BL, Receptors, Interferon, Mice, Knockout, Protein Transport, Mice

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IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

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