Alzheimer’s disease in the 100 years since Alzheimer’s death
Abstract
The last 100 years have seen major changes in concepts of the nature of Alzheimer’s disease, its prevalence and whom it affects. Ryan et al. discuss some of the factors that have contributed to this evolution, leading to contemporary views of this disorder.
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The presence of extracellular amyloid plaques and intracellular neurofibrillary tangles is required for diagnosis of Alzheimer's disease.
“As first observed over 100 years ago [25], the presence of extracellular amyloid plaques and intracellular neurofibrillary tangles is required for diagnosis.”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [25]
Cites
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941 · see citing works
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The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“As first observed over 100 years ago [25], the presence of extracellular amyloid plaques and intracellular neurofibrillary tangles is required for diagnosis.”
BackgroundMorris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works
Frontotemporal dementia: Past, present, and future
Ulugut, H., & Pijnenburg, Y. A. L. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13363 · Cited by 33 · see citing works
- Authors
- Ryan, N. S., Rossor, M. N., & Fox, N. C.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-11-04
- Volume
- 138
- Issue
- 12
- Pages
- 3816-3821
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2104977898
- Cited by
- 69
- References
- 1
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 1
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0512-10033, NF-SI-0513-10134, NF-SI-0508-10123)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- Alzheimer's disease, history of Alzheimer's disease, illness beliefs, prevalence, affected populations, history of neurology
- MeSH terms
- Alzheimer Disease, Humans, History, 20th Century, History, 21st Century
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