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Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice
Open accessAbstract
Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality. The underlying mechanism of infections has been widely investigated by scientist, while standard wound management is routinely been used in general practice. However, strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization, delayed healing and drug resistance. In the present review, we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis, non-surgical methods and surgical methods. Moreover, we highlight emerging innovations in the development of antimicrobial peptides, phages, controlled drug delivery, wound dressing materials and herbal medicine, and find that sensitive diagnostics, combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.
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Cited by
Teymouri, S., Yousefi, M. H., Heidari, S., Farokhi, S., Afkhami, H., & Kashfi, M. (2025) · Molecular Biology Reports · doi:10.1007/s11033-024-10163-x · Cited by 11
Metadata
- Authors
- Ding, X., Tang, Q., Xu, Z., Xu, Y., Zhang, H., Zheng, D., Wang, S., Tan, Q., Maitz, J., Maitz, P. K., Yin, S., Wang, Y., & Chen, J.
- Venue
- Burns & Trauma
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-01-01
- Volume
- 10
- Pages
- tkac014-tkac014
- ISSN
- 2321-3868 (ISSN-L)
- 2321-3876
- OpenAlex
- W4214834626
- Cited by
- 277
- References
- 0
- FWCI
- 17.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice. https://app.cochat.ai/papers/10.1093/burnst/tkac014
- The paper
- Ding, X., Tang, Q., Xu, Z., Xu, Y., Zhang, H., Zheng, D., Wang, S., Tan, Q., Maitz, J., Maitz, P. K., Yin, S., Wang, Y., & Chen, J. (2022). Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice. Burns & Trauma. https://doi.org/10.1093/burnst/tkac014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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