The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos
Abstract
We examined 8-hydroxyguanine (8-OH-Gua) formation and 8-OH-Gua repair enzyme activity in pulmonary type-II-like epithelial cells to determine whether oxidative stress induced by asbestos plays a role in its carcinogenic mechanism. A549 cells were incubated with crocidolite asbestos at concentrations of 0, 10, 50 and 100 microg/ml over 27 h. We then evaluated 8-OH-Gua formation, 8-OH-Gua repair enzyme activity and gene expression of 8-oxoguanine-DNA glycosylase 1 (hOGG1) and human MUtT homologue (hMTH1). This was done using a high-performance liquid chromatography system equipped with an electrochemical detector, endonuclease nicking assay and reverse transcription polymerase chain reaction, respectively. Crocidolite induced the formation of 8-OH-Gua in DNA at concentrations of 50 and 100 microg/ml. 8-OH-Gua levels increased at 9 h and had declined to near baseline at 27 h, whereas 8-OH-Gua repair enzyme activity peaked at 18 h post-crocidolite exposure. hOGG1 and hMTH1 mRNA levels were also increased by crocidolite exposure. These data suggest that crocidolite asbestos is associated with epithelial cell injury in the process of carcinogenesis through oxidative stress.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“All these factors have been linked to the formation of RNOs, the release of cytokines and growth factors promoting chronic inflammation, leukocyte invasion, and DNA damage20–22.”
From Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments (2025) · cites this paper as [22]
In the citing paper
“Asbestos carcinogenesis depends on numerous factors, including inhaled dose, dimension, physical durability, surface features, crystallinity, and chemical composition.”
From Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments (2025) · cites this paper as [22]
Citations
Cites
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
Mechanisms in the Pathogenesis of Asbestosis and Silicosis
MOSSMAN, B. T., & CHURG, A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.5.9707141 · Cited by 971
Chao, C.-C., Park, S.-H., & Aust, A. E. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0059 · Cited by 118
Research works printed but not linked: 29
- Faux, 1994, Mutation Research, 311, 209, 10.1016/0165-1218(94)90008-6 · DOI
- Mossman, 1989, Environmental Health Perspectives, 81, 91, 10.1289/ehp.898191 · DOI
- 1989, Respiratory medicine, 92, 609, 10.1016/S0954-6111(98)90506-6 · DOI
- Kasai, 1984, Nucleic Acids Research, 12, 2137, 10.1093/nar/12.4.2137 · DOI
- Cheng, 1992, Journal of Biological Chemistry, 267, 166, 10.1016/S0021-9258(18)48474-8 · DOI · Paper page
- van der Kemp, 1996, PNAS, 93, 5197, 10.1073/pnas.93.11.5197 · DOI
- Nash, 1996, Current biology : CB, 6, 968, 10.1016/S0960-9822(02)00641-3 · DOI
- Aburatani, 1997, Cancer Research, 57, 2151
- Arai, 1997, Oncogene, 14, 2857, 10.1038/sj.onc.1201139 · DOI
- Sakumi, 1993, Journal of Biological Chemistry, 268, 23524, 10.1016/S0021-9258(19)49494-5 · DOI
- Nishida, 1995, Journal of Biological Chemistry, 270, 14659, 10.1074/jbc.270.24.14659 · DOI
- Fujino, 1995, International journal of occupational and environmental health : official journal of the International Commission on Occupational Health, 1, 21, 10.1179/oeh.1995.1.1.21 · DOI
- Yamaguchi, 1996, Carcinogenesis, 17, 2419, 10.1093/carcin/17.11.2419 · DOI
- Nakae, 1995, Cancer letters, 97, 233, 10.1016/0304-3835(95)03980-B · DOI
- Yamamoto, 1992, Cancer Science, 83, 351, 10.1111/j.1349-7006.1992.tb00114.x · DOI
- Roldan-Arjona, 1997, PNAS, 94, 8016, 10.1073/pnas.94.15.8016 · DOI
- Wisp, 1989, Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology, 994, 30, 10.1016/0167-4838(89)90058-7 · DOI
- Wiesner, 1991, American Journal of Physiology - Lung Cellular and Molecular Physiology, 260, L179, 10.1152/ajplung.1991.260.4.L179 · DOI
- Takahashi, 1997, International journal of occupational and environmental health : official journal of the International Commission on Occupational Health, 3, 111, 10.1179/oeh.1997.3.2.111 · DOI
- Takeuchi, 1994, Carcinogenesis, 15, 635, 10.1093/carcin/15.4.635 · DOI
- Fung, 1997, Carcinogenesis, 18, 825, 10.1093/carcin/18.4.825 · DOI
- Adachi, 1994, Carcinogenesis, 15, 753, 10.1093/carcin/15.4.753 · DOI
- Murata-Kamiya, 1997, International archives of occupational and environmental health, 70, 321, 10.1007/s004200050225 · DOI
- 1999, Cancer Science, 90, 505, 10.1111/j.1349-7006.1999.tb00776.x · DOI
- Fung, 1998, Cancer Research, 58, 189
- Bessho, 1993, PNAS, 90, 8901, 10.1073/pnas.90.19.8901 · DOI
- 1998, Nucleic Acids Research, 26, 5116, 10.1093/nar/26.22.5116 · DOI
- Kennedy, 1998, FEBS Letters, 429, 17, 10.1016/S0014-5793(98)00505-5 · DOI
- Maki, 1992, Nature; Physical Science (London), 355, 273, 10.1038/355273a0 · DOI
Cited by
Sorted by citations
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Role of Mutagenicity in Asbestos Fiber-Induced Carcinogenicity and Other Diseases
Huang, S. X. L., Jaurand, M.-C., Kamp, D. W., Whysner, J., & Hei, T. K. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.556051 · Cited by 163
Aung, W., Hasegawa, S., Furukawa, T., & Saga, T. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm090 · Cited by 62
Burmeister, B., Schwerdtle, T., Poser, I., Hoffmann, E., Hartwig, A., Müller, W.-U., Rettenmeier, A. W., Seemayer, N. H., & Dopp, E. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.11.003 · Cited by 52
Cytotoxicity and DNA-damage in human lung epithelial cells exposed to respirable α-quartz
Fanizza, C., Ursini, C. L., Paba, E., Ciervo, A., Di Francesco, A., Maiello, R., De Simone, P., & Cavallo, D. (2007) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.12.002 · Cited by 44
Metadata
- Authors
- Kim, H.-N., Morimoto, Y., Tsuda, T., Ootsuyama, Y., Hirohashi, M., Hirano, T., Tanaka, I., Lim, Y., Yun, I.-G., & Kasai, H.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02-01
- Volume
- 22
- Issue
- 2
- Pages
- 265-269
- ISSN
- 0143-3334
- 1460-2180
- Cited by
- 65
- References
- 3
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
