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Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro
Abstract
S-Adenosylmethionine was found to methylate DNA non-enzymatically to produce the same putative promutagenic and procarcinogenic lesions formed by carcinogenic chemical methylating agents. The formation of 7-methylguanine was confirmed by u.v. spectrophotometry, the formation of O6-methylguanine and 3-methyladenine was suggested by the cochromatography of radioactivity with standard bases. It is possible that this reaction may explain the presence of constitutive cellular enzymes specifically for the repair of methylated DNA, and may indicate the mechanism whereby methylated guanine is formed in the liver DNA of rats with chemically induced liver damage.
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Citations
Cited by
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli
Walker, G. C. (1984) · Microbiological Reviews · doi:10.1128/mmbr.48.1.60-93.1984 · Cited by 1,770
Motorin, Y., & Helm, M. (2011) · WIREs RNA · doi:10.1002/wrna.79 · Cited by 441
Dango, S., Mosammaparast, N., Sowa, M. E., Xiong, L.-J., Wu, F., Park, K., Rubin, M., Gygi, S., Harper, J. W., & Shi, Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.039 · Cited by 216
Autocatalytic chemical networks at the origin of metabolism
Xavier, J. C., Hordijk, W., Kauffman, S., Steel, M., & Martin, W. F. (2020) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2019.2377 · Cited by 196
Metadata
- Authors
- Barrows, L. R., & Magee, P. N.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1982
- Volume
- 3
- Issue
- 3
- Pages
- 349-351
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2089215158
- Cited by
- 160
- References
- 0
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barrows, L. R., & Magee, P. N. (1982). Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro. Carcinogenesis. https://doi.org/10.1093/carcin/3.3.349
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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