Cited by 130Carcinogens and Genotoxicity AssessmentArsenic contamination and mitigationEpigenetics and DNA Methylation

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Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells

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Sciandrello, G.·2003·Carcinogenesis

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Abstract

Early genetic instability induced in dividing V79-Cl3 Chinese hamster cells by inorganic arsenic, as demonstrated in our previous investigation, was evidenced by aneuploidy and nuclear abnormalities, but not by chromosomal rearrangements. Here we report the results of cytogenetic and morphological analyses performed on the progeny of cells dividing at the end of sodium arsenite treatment after they had been expanded through 120 generations (ASO cells) and then cloned. The acquired genetic instability persisted and was increased by highly unstable chromosomal rearrangements, namely dicentric chromosomes and telomeric associations, which were not seen following acute exposure. A peculiar finding was the preferential involvement of a particular chromosome in dicentric rearrangements observed in some isolated ASO clones. Interestingly, by immunostaining with anti-5-methylcytosine antibodies the genome-wide DNA hypomethylation, induced by arsenic immediately after the acute treatment, was found to affect those ASO clones characterized by aneuploidy and chromosomal rearrangements. These findings demonstrate that short-term exposure to arsenic has long-term effects and suggest that genome-wide DNA hypomethylation enhances genetic instability.

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Authors: Sciandrello, G.
Affiliations: University of Palermo (IT)
Corresponding author: Sciandrello, G.
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 2003-12-04
Volume: 25
Issue: 3
Pages: 413-417
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/bgh029
OpenAlex: W2116476764
Cited by: 130
References: 25
Citations by year: 2026: 1 · 2025: 2 · 2023: 4 · 2022: 6 · 2021: 5 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 15 · 2013: 11 · 2012: 10
FWCI: 1.12
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: inorganic arsenic, sodium arsenite, DNA hypomethylation, chromosomal instability, genomic instability, dicentric chromosomes, chromosomal rearrangements, aneuploidy, telomeric associations, 5-methylcytosine, long-term exposure effects
MeSH terms: Animals, Antineoplastic Agents, Arsenic, Carcinogens, Chromosome Aberrations, Cricetinae, DNA Methylation, Cytogenetic Analysis, Chromosomal Instability

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Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells

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