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Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma
Open accessAbstract
To elucidate the relationship between tumor genesis and the mitochondrial energy metabolism in renal neoplasms, we studied three individual enzyme activities of the oxidative phosphorylation, two components of the Krebs cycle and the mitochondrial DNA content of renal carcinomas including 29 conventional, five papillary, two unclassified carcinomas with sarcomatoid features and one collecting duct carcinoma. A significant reduction of all mitochondrial enzyme activities including complex V, as well as of the mitochondrial DNA content was detected in 34 of 37 renal carcinoma tissues as compared with control kidney. Mitochondrial enzyme activities and mitochondrial DNA levels were not statistically different between the conventional, papillary and unclassified sarcomatoid type of renal carcinoma and did not correlate with tumour grade, metastasis, ploidy and proliferative activity as determined by Ki-67 staining. Taken together, our data indicate that a co-ordinated down-regulation of all components necessary for mitochondrial energy metabolism occurs in most renal carcinomas as an early event in carcinoma formation, which does not change with progression of the disease.
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Cited by
Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885
Campbell, C. T., Kolesar, J. E., & Kaufman, B. A. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.002 · Cited by 462
VHL and HIF signalling in renal cell carcinogenesis
Baldewijns, M. M., van Vlodrop, I. J., Vermeulen, P. B., Soetekouw, P. M., van Engeland, M., & de Bruïne, A. P. (2010) · The Journal of Pathology · doi:10.1002/path.2689 · Cited by 316
Wu, L. L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T.-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J., & Robker, R. L. (2015) · Development · doi:10.1242/dev.114850 · Cited by 276
Koch, J., Feichtinger, R. G., Freisinger, P., Pies, M., Schrödl, F., Iuso, A., Sperl, W., Mayr, J. A., Prokisch, H., & Haack, T. B. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103500 · Cited by 127
Metadata
- Authors
- Meierhofer, D.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-04
- Volume
- 25
- Issue
- 6
- Pages
- 1005-1010
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2147875287
- Cited by
- 164
- References
- 0
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Meierhofer, D. (2004). Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis. https://doi.org/10.1093/carcin/bgh104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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