Medial Prefrontal Cortex 5-HT2A Density Is Correlated with Amygdala Reactivity, Response Habituation, and Functional Coupling
Open accessAbstract
Feedback inhibition of the amygdala via medial prefrontal cortex (mPFC) is an important component in the regulation of complex emotional behaviors. The functional dynamics of this corticolimbic circuitry are, in part, modulated by serotonin (5-HT). Serotonin 2A (5-HT(2A)) receptors within the mPFC represent a potential molecular mechanism through which 5-HT can modulate this corticolimbic circuitry. We employed a multimodal neuroimaging strategy to explore the relationship between threat-related amygdala reactivity, assessed using blood oxygen level-dependent functional magnetic resonance imaging, and mPFC 5-HT(2A) density, assessed using [(18)F]altanserin positron emission tomography in 35 healthy adult volunteers. We observed a significant inverse relationship wherein greater mPFC 5-HT(2A) density was associated with reduced threat-related right amygdala reactivity. Remarkably, 25-37% of the variability in amygdala reactivity was explained by mPFC 5-HT(2A) density. We also observed a positive correlation between mPFC 5-HT(2A) density and the magnitude of right amygdala habituation. Furthermore, functional coupling between the amygdala and mPFC was positively correlated with 5-HT(2A) density suggesting that effective integration of emotionally salient information within this corticolimbic circuitry may be modulated, at least in part, by mPFC 5-HT(2A). Collectively, our results indicate that mPFC 5-HT(2A) is strongly associated with threat-related amygdala reactivity as well as its temporal habituation and functional coupling with prefrontal regulatory regions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
mPFC 5-HT2A receptor density measured using [18F]-altanserin correlated negatively with right amygdala fMRI activity and positively with mPFC-amygdala functional coupling.
“and that medial prefrontal cortex (mPFC) 5-HT 2A receptor density, measured using [ 18 F]-altanserin, correlated negatively with right amygdala fMRI activity and positively with mPFC-amygdala functional coupling (Fisher et al., 2009).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Fisher et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 83 · Cited by 125
- Authors
- Fisher, P. M., Meltzer, C. C., Price, J. C., Coleman, R. L., Ziolko, S. K., Becker, C., Moses-Kolko, E. L., Berga, S. L., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Emory University (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03-25
- Volume
- 19
- Issue
- 11
- Pages
- 2499-2507
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2758681
- OpenAlex
- W2118969780
- Cited by
- 125
- References
- 83
- Citations by year
- 2026: 4 · 2025: 4 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 10 · 2013: 11 · 2012: 13
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH079164, MH 064625, K24MH064625, MH072837, MH067602, K01MH072837, R01MH067602)
- National Institute on Drug Abuse (DA023420, R90DA023420)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- medial prefrontal cortex, 5-HT2A receptor, amygdala reactivity, functional coupling, corticolimbic circuitry, emotion regulation
- MeSH terms
- Adult, Amygdala, Emotions, Female, Habituation, Psychophysiologic, Humans, Male, Neural Inhibition, Tissue Distribution, Prefrontal Cortex, Receptor, Serotonin, 5-HT2A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
