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Cited by 129Transcranial Magnetic Stimulation StudiesNeural dynamics and brain functionNeural and Behavioral Psychology Studies

Enhancement of working memory and task-related oscillatory activity following intermittent theta burst stimulation in healthy controls

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Hoy, Kate E., Bailey, Neil, Michael, Marco, Fitzgibbon, Bernadette, Rogasch, Nigel C., Saeki, Takashi, Fitzgerald, Paul B.·2016·Cerebral Cortex
DOI 10.1093/cercor/bhv193
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Abstract

Noninvasive brain stimulation is increasingly being investigated for the enhancement of cognition, yet current approaches appear to be limited in their degree and duration of effects. The majority of studies to date have delivered stimulation in "standard" ways (i.e., anodal transcranial direct current stimulation or high-frequency transcranial magnetic stimulation). Specialized forms of stimulation, such as theta burst stimulation (TBS), which more closely mimic the brains natural firing patterns may have greater effects on cognitive performance. We report here the findings from the first-ever investigation into the persistent cognitive and electrophysiological effects of intermittent TBS (iTBS) delivered to the left dorsolateral prefrontal cortex. In 19 healthy controls, active iTBS significantly improved performance on an assessment of working memory when compared with sham stimulation across a period of 40 min post stimulation. The behavioral findings were accompanied by increases in task-related fronto-parietal theta sychronization and parietal gamma band power. These results have implications for the role of more specialized stimulation approaches in neuromodulation.

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Authors
Hoy, K. E., Bailey, N., Michael, M., Fitzgibbon, B., Rogasch, N. C., Saeki, T., & Fitzgerald, P. B.
Affiliations
  • The Alfred Hospital (AU)
  • Monash University (AU)
Corresponding author
Hoy, Kate E.
ORCID
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2015-09-23
Volume
26
Issue
12
Pages
4563-4573
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/bhv193
OpenAlex
W2337709795
Cited by
129
References
4
Citations by year
2026: 13 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 11 · 2021: 23 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 5 · 2016: 4
FWCI
3.38
Type
journal article
Language
en
Open access
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • National Health and Medical Research Council
  • Monash University
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
intermittent theta burst stimulation, working memory, dorsolateral prefrontal cortex, non-invasive brain stimulation, neuromodulation, theta synchronization, gamma power, cognitive enhancement, sham stimulation
MeSH terms
Cortical Synchronization, Female, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Parietal Lobe, Reaction Time, Signal Processing, Computer-Assisted, Theta Rhythm, Single-Blind Method, Prefrontal Cortex, Transcranial Magnetic Stimulation, Young Adult, Gamma Rhythm

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