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Human Metabolic Profiles Obtained by GC and GC/MS
Abstract
Metabolic profiles can be obtained by gas phase analytical methods for many types of human metabolic products. These include urinary steroids, urinary and blood sugars and sugar alcohols, urinary and blood acids; compounds of the Krebs cycle and related substances; and drug metabolites in blood or urine. Changes in profiles can be studied for pathologic circumstances and after drug therapy. The methods are particularly useful for drug metabolism studies. The instrumental techniques are those of combined GC-MS. Multicomponent analyses are carried out by temperature programming, and the identity of each component is determined by MS. Appropriate derivatives must be prepared for each type of separation.
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Citations
Cited by
Current approaches and challenges for the metabolite profiling of complex natural extracts
Wolfender, J.-L., Marti, G., Thomas, A., & Bertrand, S. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.091 · Cited by 635
Kuehnbaum, N. L., & Britz-McKibbin, P. (2013) · Chemical Reviews · doi:10.1021/cr300484s · Cited by 354
Overview of Mass Spectrometry-Based Metabolomics: Opportunities and Challenges
Gowda, G. A. N., & Djukovic, D. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-4939-1258-2_1 · Cited by 334
Pharmacometabonomics and personalized medicine
Everett, J. R., Loo, R. L., & Pullen, F. S. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563213497929 · Cited by 75
Metadata
- Authors
- Horning, E. C., & Horning, M. G.
- Venue
- Journal of Chromatographic Science
- Publisher
- Oxford University Press (OUP)
- Published
- 1971-03-01
- Volume
- 9
- Issue
- 3
- Pages
- 129-140
- ISSN
- 0021-9665 (ISSN-L)
- 1945-239X
- OpenAlex
- W2317553488
- Cited by
- 174
- References
- 0
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human Metabolic Profiles Obtained by GC and GC/MS. https://app.cochat.ai/papers/10.1093/chromsci/9.3.129
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- Horning, E. C., & Horning, M. G. (1971). Human Metabolic Profiles Obtained by GC and GC/MS. Journal of Chromatographic Science. https://doi.org/10.1093/chromsci/9.3.129
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