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Cited by 380

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-β-lactamase–Producing Enterobacterales

Falcone, Marco, Daikos, George L, Tiseo, Giusy, Bassoulis, Dimitrios, Giordano, Cesira, Galfo, Valentina, Leonildi, Alessandro, Tagliaferri, Enrico, Barnini, Simona, Sani, Spartaco, Farcomeni, Alessio, Ghiadoni, Lorenzo, Menichetti, Francesco·2021·Clinical Infectious Diseases
DOI 10.1093/cid/ciaa586
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Abstract

Background: In vitro data support the use of combination of aztreonam (ATM) with ceftazidime-avibactam (CAZ-AVI), but clinical studies are lacking. The aim of our study was to compare the outcome of patients with bloodstream infections (BSIs) due to metallo-β-lactamase (MBL)–producing Enterobacterales treated either with CAZ-AVI plus ATM or other active antibiotics (OAAs). Methods: This was a prospective observational study including patients admitted to 3 hospitals in Italy and Greece. The primary outcome measure was 30-day all-cause mortality. Secondary outcomes were clinical failure at day 14 and length of stay after BSI diagnosis. Cox regression analysis including a propensity score (PS) for receiving CAZ-AVI + ATM was performed to evaluate primary and secondary outcomes. A PS-based matched analysis was also performed. Results: We enrolled 102 patients with BSI; 82 had infections caused by NDM-producing (79 Klebsiella pneumoniae and 3 Escherichia coli) and 20 by VIM-producing (14 K. pneumoniae, 5 Enterobacter species, 1 Morganella morganii) strains. The 30-day mortality rate was 19.2% in the CAZ-AVI + ATM group vs 44% in the OAA group (P = .007). The PS-adjusted analysis showed that the use of CAZ-AVI + ATM was associated with lower 30-day mortality (hazard ratio [HR], 0.37 [95% confidence interval {CI}, .13–.74]; P = .01), lower clinical failure at day 14 (HR, 0.30 [95% CI, .14–.65]; P = .002), and shorter length of stay (subdistributional HR, 0.49 [95% CI, .30–.82]; P = .007). The PS-matched analysis confirmed these findings. Conclusions: The CAZ-AVI + ATM combination offers a therapeutic advantage compared to OAAs for patients with BSI due to MBL-producing Enterobacterales. Further studies are warranted.

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Metadata

Authors
Falcone, M., Daikos, G. L., Tiseo, G., Bassoulis, D., Giordano, C., Galfo, V., Leonildi, A., Tagliaferri, E., Barnini, S., Sani, S., Farcomeni, A., Ghiadoni, L., & Menichetti, F.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2020-05-19
Volume
72
Issue
11
Pages
1871-1878
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1093/cid/ciaa586
OpenAlex
W3026777707
Cited by
380
References
23
FWCI
12.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-β-lactamase–Producing Enterobacterales. https://app.cochat.ai/papers/10.1093/cid/ciaa586
The paper
Falcone, M., Daikos, G. L., Tiseo, G., Bassoulis, D., Giordano, C., Galfo, V., Leonildi, A., Tagliaferri, E., Barnini, S., Sani, S., Farcomeni, A., Ghiadoni, L., & Menichetti, F. (2021). Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-β-lactamase–Producing Enterobacterales. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa586

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.