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Biological and Analytic Components of Variation in Long-Term Studies of Serum Constituents in Normal Subjects
Abstract
A study of blood constituents in normal individuals was undertaken to (a) estimate the contribution of biological and analytical factors to the variation of constituents over an extended time period; (b) to explore whether such tests can be used to derive meaningful personal blood "profiles"; and (c) to determine when analytic variation may become large enough to assume medical significance. This first paper describes procedures for subject selection, the laboratory methods employed, and evaluates analytic standard deviations. A group of 68 normal subjects was selected after medical evaluation. Sera were collected and analyzed in duplicate weekly for 10 to 12 weeks. Analytic deviation was estimated from the results of concurrent daily analyses of sterile pools of human serum. Laboratory procedures were introduced to reduce analytic deviation and to allow more accurate estimation of biological components of variation within and among individuals.
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Cited by
Andersen, S., Pedersen, K. M., Bruun, N. H., & Laurberg, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8165 · Cited by 686
Use and Interpretation of Common Statistical Tests in Method Comparison Studies
Westgard, J. O. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.094060 · Cited by 310
Biologic Variation is Important for Interpretation of Thyroid Function Tests
Andersen, S., Bruun, N. H., Pedersen, K. M., & Laurberg, P. (2003) · Thyroid · doi:10.1089/105072503770867237 · Cited by 241
Boyd, J. C., & Bruns, D. E. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.2.209 · Cited by 227
Analytical performance characteristics should be judged against objective quality specifications
Fraser, C. G., & Petersen, P. H. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.3.321 · Cited by 194
Metadata
- Authors
- Williams, G. Z., Young, D. S., Stein, M. R., & Cotlove, E.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1970-12-01
- Volume
- 16
- Issue
- 12
- Pages
- 1016-1021
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2519279601
- Cited by
- 217
- References
- 0
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Biological and Analytic Components of Variation in Long-Term Studies of Serum Constituents in Normal Subjects. https://app.cochat.ai/papers/10.1093/clinchem/16.12.1016
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- Williams, G. Z., Young, D. S., Stein, M. R., & Cotlove, E. (1970). Biological and Analytic Components of Variation in Long-Term Studies of Serum Constituents in Normal Subjects. Clinical Chemistry. https://doi.org/10.1093/clinchem/16.12.1016
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
