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Influence of Statistical Method Used on the Resulting Estimate of Normal Range
Abstract
The choice of statistical method can greatly influence the calculated normal range apart from any biological or chemical considerations. Nonparametric normal range estimates are, for practical purposes, as accurate as estimates that assume the distribution of data to be gaussian or loggaussian when the distribution assumed is true. When data are not distributed as assumed, nonparametric estimates are more accurate.
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Cited by
Biino, G., Santimone, I., Minelli, C., Sorice, R., Frongia, B., Traglia, M., Ulivi, S., Di Castelnuovo, A., Gögele, M., Nutile, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054289 · Cited by 227
Reference intervals: the way forward
Ceriotti, F., Hinzmann, R., & Panteghini, M. (2009) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008170 · Cited by 199
Ueland, G. Å., Methlie, P., Kellmann, R., Bjørgaas, M., Åsvold, B. O., Thorstensen, K., Kelp, O., Thordarson, H. B., Mellgren, G., Løvås, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0078 · Cited by 94
Dathan-Stumpf, A., Vogel, M., Hiemisch, A., Thiery, J., Burkhardt, R., Kratzsch, J., & Kiess, W. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.02.010 · Cited by 75
The short cosyntropin test revisited: new normal reference range using LC-MS/MS
Ueland, G. Å., Methlie, P., Øksnes, M., Thordarson, H. B., Sagen, J., Kellmann, R., Mellgren, G., Ræder, M., Dahlqvist, P., Dahl, S. R., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02602 · Cited by 71
Metadata
- Authors
- Reed, A. H., Henry, R. J., & Mason, W. B.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1971-04-01
- Volume
- 17
- Issue
- 4
- Pages
- 275-284
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1930145556
- Cited by
- 531
- References
- 0
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Influence of Statistical Method Used on the Resulting Estimate of Normal Range. https://app.cochat.ai/papers/10.1093/clinchem/17.4.275
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- Reed, A. H., Henry, R. J., & Mason, W. B. (1971). Influence of Statistical Method Used on the Resulting Estimate of Normal Range. Clinical Chemistry. https://doi.org/10.1093/clinchem/17.4.275
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