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An Analytical System for Rapid Separation of Tissue Nucleotides at Low Pressures on Conventional Anion Exchangers
Abstract
An analytical anion-exchange procedure has been developed for the rapid separation of acid-soluble nucleotides (the so-called "free" or tissue nucleotides). It permits assay at low pressures (275-415 kPa; 40-60 psi) in less than 1 h on 10-cm columns of Aminex resins (conventional styrene-type anion exchangers) with alkaline citrate solutions as the eluent. Separation variables have been investigated, to determine optimum conditions for the routine analysis of samples containing tissue nucleotides. Also described here is a simple solvent-extraction procedure for removing HClO4 or CCl3CO2H quantitatively from cell extracts that contain acid-soluble nucleotides: they are removed from aqueous acid solutions with a water-insoluble amine dissolved in a water-immiscible solvent.
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Citations
Cited by
Schraufstatter, I. U., Hinshaw, D. B., Hyslop, P. A., Spragg, R. G., & Cochrane, C. G. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112436 · Cited by 512
Partida-Sanchez, S., Gasser, A., Fliegert, R., Siebrands, C. C., Dammermann, W., Shi, G., Mousseau, B. J., Sumoza-Toledo, A., Bhagat, H., Walseth, T. F., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7827 · Cited by 144
Metadata
- Authors
- Khym, J. X.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1975-08-01
- Volume
- 21
- Issue
- 9
- Pages
- 1245-1252
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2096725836
- Cited by
- 530
- References
- 0
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An Analytical System for Rapid Separation of Tissue Nucleotides at Low Pressures on Conventional Anion Exchangers. https://app.cochat.ai/papers/10.1093/clinchem/21.9.1245
- The paper
- Khym, J. X. (1975). An Analytical System for Rapid Separation of Tissue Nucleotides at Low Pressures on Conventional Anion Exchangers. Clinical Chemistry. https://doi.org/10.1093/clinchem/21.9.1245
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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